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Attention à la créatine éthyl ester (CEE)

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Attention à la créatine éthyl ester (CEE)

Messagepar Nutrimuscle-Conseils » 7 Oct 2009 03:47

Int J Sports Med 2009; 30: 766-770

Qualitative In vitro NMR Analysis of Creatine Ethyl Ester Pronutrient in Human Plasma

M. W. Giese1, C. S. Lecher1
1Marian College, Chemistry, Indianapolis, United States

There are a number of forms of creatine available that attempt to improve the solubility and permeability, with the anticipation this will result in an improved pharmacokinetic profile and ultimately an enhanced ergogenic response. Previous research has shown that the different salt forms can improve solubility resulting in slightly altered pharmacokinetic profiles, however specific data exploring the conversion of esterified derivatives to creatine is lacking. The purpose of this study was to examine the assertion that creatine ethyl ester undergoes enzymatic conversion to creatine in human tissues. The in vitro response of creatine ethyl ester to incubation in human plasma was examined by H-NMR analysis. Lyophilized human plasma was reconstituted in D2O and phosphate-buffered saline and 1.5 mg of the analyte was added. Following incubation at 37°C for 4 h and subsequent protein precipitation, the supernatant was analyzed by NMR, utilizing the diagnostic chemical shift of the methylene signal to determine the species present in solution, i.e. creatine ethyl ester, creatine, or creatinine. Both creatine and creatinine were run in parallel as control experiments and each assay was run in triplicate. As expected both creatine and creatinine remained unchanged. However, conversion of creatine ethyl ester to creatine by the esterases in human plasma was not observed to any detectable extent and the only species detected after the incubation period was creatinine. While not a definitive characterization of the in vivo behavior, these results strongly warrant a complete in vivo pharmacokinetic analysis of creatine ethyl ester since it appears these “pronutrients” may actually provide large exogenous sources of pharmacologically inactive creatinine rather than ergogenic creatine.
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Messagepar chibani34 » 7 Oct 2009 06:46

c est toxique?
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Messagepar Nutrimuscle-Conseils » 7 Oct 2009 09:53

c'est pas bon
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Messagepar chibani34 » 7 Oct 2009 20:25

c est comme le serum de créatine alors?ils ent faisaient tout un cinema comme quoi c etait le top et en faite c est mauvais
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Messagepar Nutrimuscle-Conseils » 7 Oct 2009 20:43

plus il y a de cinéma sur la créatinine, plus il y a de chances que leurs produits en soient blindés
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Messagepar thanos999 » 8 Oct 2009 16:47

Hier a un gars qui ma sorti que la créatine sa empêchait de bander :lol:

Il avait 2 de ces potes qui en avaient pris; ils avait 2 fois plus de forces mais ils bandaient plus
A mon avis ils avaient du prendre autre chose :lol:
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