Nutrimuscle Forum : Mobile & Tablette

Créatine Ethyl Ester se tranforme facilement en créatinine

Actualités sport, fitness & musculation, vidéos des pros, études scientifiques. Discutez avec la communauté Nutrimuscle et partagez votre expérience...

Modérateurs: Nutrimuscle-Conseils, Nutrimuscle-Diététique

Créatine Ethyl Ester se tranforme facilement en créatinine

Messagepar Nutrimuscle-Conseils » 20 Jan 2010 11:27

elle est donc à éviter

Qualitative In vitro NMR Analysis of Creatine Ethyl Ester Pronutrient in Human Plasma
Int J Sports Med 2009; 30(10): 766-770 M. W. Giese, C. S. Lecher

There are a number of forms of creatine available that attempt to improve the solubility and permeability, with the anticipation this will result in an improved pharmacokinetic profile and ultimately an enhanced ergogenic response. Previous research has shown that the different salt forms can improve solubility resulting in slightly altered pharmacokinetic profiles, however specific data exploring the conversion of esterified derivatives to creatine is lacking. The purpose of this study was to examine the assertion that creatine ethyl ester undergoes enzymatic conversion to creatine in human tissues. The in vitro response of creatine ethyl ester to incubation in human plasma was examined by H-NMR analysis. Lyophilized human plasma was reconstituted in D2O and phosphate-buffered saline and 1.5 mg of the analyte was added. Following incubation at 37°C for 4 h and subsequent protein precipitation, the supernatant was analyzed by NMR, utilizing the diagnostic chemical shift of the methylene signal to determine the species present in solution, i.e. creatine ethyl ester, creatine, or creatinine. Both creatine and creatinine were run in parallel as control experiments and each assay was run in triplicate. As expected both creatine and creatinine remained unchanged. However, conversion of creatine ethyl ester to creatine by the esterases in human plasma was not observed to any detectable extent and the only species detected after the incubation period was creatinine. While not a definitive characterization of the in vivo behavior, these results strongly warrant a complete in vivo pharmacokinetic analysis of creatine ethyl ester since it appears these “pronutrients” may actually provide large exogenous sources of pharmacologically inactive creatinine rather than ergogenic creatine.
Avatar de l’utilisateur
Nutrimuscle-Conseils
Forum Admin
 
Messages: 38811
Inscription: 11 Sep 2008 19:11

Messagepar LAYO41 » 20 Jan 2010 14:53

C'était pas un créatine censée être mieux assimilée par les muscles ? (Y'a pas forcément de rapport avec le sujet de base d'ailleurs, c'est plus pour le complément d'info)
Avatar de l’utilisateur
LAYO41
 
Messages: 315
Inscription: 8 Nov 2009 23:58
Localisation: Longwy

Messagepar 3utcher » 22 Jan 2010 20:35

C'est un argument marketting mis en avant par les marques.
Avatar de l’utilisateur
3utcher
 
Messages: 207
Inscription: 3 Déc 2008 07:54

Messagepar Nutrimuscle-Conseils » 23 Jan 2010 01:28

LAYO41 a écrit:C'était pas un créatine censée être mieux assimilée par les muscles ?


oui
Avatar de l’utilisateur
Nutrimuscle-Conseils
Forum Admin
 
Messages: 38811
Inscription: 11 Sep 2008 19:11


Retourner vers Actualités, vidéos, études scientifiques

Qui est en ligne

Utilisateurs parcourant ce forum: Aucun utilisateur enregistré et 4 invités