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Les polyphénols accélèrent la récupération musculaire

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Les polyphénols accélèrent la récupération musculaire

Messagepar Nutrimuscle-Conseils » 11 Aoû 2012 14:50

Accelerated skeletal muscle recovery after in vivo polyphenol administration
The Journal of Nutritional Biochemistry Volume 23, Issue 9, September 2012, Pages 1072–1079 Kathryn H. Myburgh

Acute skeletal muscle damage results in fiber disruption, oxidative stress and inflammation. We investigated cell-specific contributions to the regeneration process after contusion-induced damage (rat gastrocnemius muscle) with or without chronic grape seed-derived proanthocyanidolic oligomer (PCO) administration. In this placebo-controlled study, male Wistar rats were subjected to PCO administration for 2 weeks, after which they were subjected to a standardised contusion injury. Supplementation was continued after injury. Immune and satellite cell responses were assessed, as well as oxygen radical absorption capacity and muscle regeneration. PCO administration resulted in a rapid satellite cell response with an earlier peak in activation (Pax7+, CD56+, at 4 h post-contusion) vs. placebo groups (PLA) (P<.001: CD56+ on Day 5 and Pax7+ on Day 7). Specific immune-cell responses in PLA followed expected time courses (neutrophil elevation on Day 1; sustained macrophage elevation from Days 3 to 5). PCO dramatically decreased neutrophil elevation to nonsignificant, while macrophage responses were normal in extent, but significantly earlier (peak between Days 1 and 3) and completely resolved by Day 5. Anti-inflammatory cytokine, IL-10, increased significantly only in PCO (Day 3). Muscle fiber regeneration (MHCf content and central nuclei) started earlier and was complete by Day 14 in PCO, but not in PLA. Thus,

responses by three crucial cell types involved in muscle recovery were affected by in vivo administration of a specific purified polyphenol in magnitude (neutrophil), time course (macrophages), or time course and activation state (satellite cell), explaining faster effective regeneration in the presence of proanthocyanidolic oligomers.
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