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La créatine aide les diabétiques

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La créatine aide les diabétiques

Messagepar Nutrimuscle-Conseils » 17 Avr 2011 17:20

en améliorant leur glycémie

Creatine in Type 2 Diabetes: A Randomized, Double-Blind, Placebo-Controlled Trial

Medicine & Science in Sports & Exercise: May 2011 - Volume 43 - Issue 5 - pp 770-778 GUALANO, BRUNO

Creatine supplementation improves glucose tolerance in healthy subjects.

Purposes: The aim was to investigate whether creatine supplementation has a beneficial effect on glycemic control of type 2 diabetic patients undergoing exercise training.

Methods: A 12-wk randomized, double-blind, placebo-controlled trial was performed. The patients were allocated to receive either creatine (CR) (5 g·d−1) or placebo (PL) and were enrolled in an exercise training program. The primary outcome was glycosylated hemoglobin (HbA1c). Secondary outcomes included the area under the curve of glucose, insulin, and C-peptide and insulin sensitivity indexes. Physical capacity, lipid profile, and GLUT-4 protein expression and translocation were also assessed.

Results: Twenty-five subjects were analyzed (CR: n = 13; PL: n = 12). HbA1c was significantly reduced in the creatine group when compared with the placebo group (CR: PRE = 7.4 ± 0.7, POST = 6.4 ± 0.4; PL: PRE = 7.5 ± 0.6, POST = 7.6 ± 0.7; P = 0.004; difference = −1.1%, 95% confidence interval = −1.9% to −0.4%). The delta area under the curve of glucose concentration was significantly lower in the CR group than in the PL group (CR = −7790 ± 4600, PL = 2008 ± 7614; P = 0.05). The CR group also presented decreased glycemia at times 0, 30, and 60 min during a meal tolerance test and increased GLUT-4 translocation. Insulin and C-peptide concentrations, surrogates of insulin sensitivity, physical capacity, lipid profile, and adverse effects were comparable between the groups.

Conclusions: Creatine supplementation combined with an exercise program improves glycemic control in type 2 diabetic patients. The underlying mechanism seems to be related to an increase in GLUT-4 recruitment to the sarcolemma.
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Messagepar 3utcher » 15 Aoû 2012 00:08

désolé de remonter ce vieux post

Tu dis tout le temps que la créatine est hypoglycémiante ; or je ne trouve pas de référence sur des humains en bonne santé (là ça parle de diabétiques).
Est-ce que tu l'aurais ?
(je n'ai pas le guide sur moi)
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Messagepar Nutrimuscle-Conseils » 15 Aoû 2012 00:35

La réf fait partie des choses que je garde pour moi mais elle existe et tu aura beau chercher tu ne la trouvera pas
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Messagepar 3utcher » 15 Aoû 2012 00:56

:shock: :roll:
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