Nutrimuscle Forum : Mobile & Tablette

Les oméga 3 protégent la peau des méfaits du soleil

Actualités sport, fitness & musculation, vidéos des pros, études scientifiques. Discutez avec la communauté Nutrimuscle et partagez votre expérience...

Modérateurs: Nutrimuscle-Conseils, Nutrimuscle-Diététique

Les oméga 3 protégent la peau des méfaits du soleil

Messagepar Nutrimuscle-Conseils » 21 Fév 2013 03:47

faite le plein avant que le soleil revienne

Randomized controlled trial of oral omega-3 PUFA in solar-simulated radiation-induced suppression of human cutaneous immune responses
Suzanne M Pilkington Am J Clin Nutr March 2013 vol. 97 no. 3 646-652

Background: Skin cancer is a major public health concern, and the majority of cases are caused by solar ultraviolet radiation (UVR) exposure, which suppresses skin immunity. Omega-3 (n−3) PUFAs protect against photoimmunosuppression and skin cancer in mice, but the impact in humans is unknown.

Objectives: We hypothesized that EPA-rich n−3 PUFA would abrogate photoimmunosuppression in humans. Therefore, a nutritional study was performed to assess the effect on UVR suppression of cutaneous cell-mediated immunity (CMI) reflected by nickel contact hypersensitivity (CHS).

Design: In a double-blind, randomized controlled study, 79 volunteers (nickel-allergic women, 22–60 y old, with phototype I or II) took 5 g n−3 PUFA–containing lipid (70% EPA plus 10% DHA) or a control lipid daily for 3 mo. After supplementation, nickel was applied to 3 skin sites preexposed on 3 consecutive days to 1.9, 3.8, or 7.6 J/cm2 of solar-simulated radiation (SSR) and to 3 unexposed control sites. Nickel CHS responses were quantified after 72 h and the percentage of immunosuppression by SSR was calculated. Erythrocyte [red blood cell (RBC)] EPA was measured by using gas chromatography.

Results: SSR dose-related suppression of the nickel CHS response was observed in both groups. Photoimmunosuppression appeared less in the n−3 PUFA group than in the control group (not statistically significant [mean difference (95% CI): 6.9% (−2.1%, 15.9%)]). The difference was greatest at 3.8 J/cm2 SSR [mean difference: 11% (95% CI: 0.5%, 21.4%)]. Postsupplementation RBC EPA was 4-fold higher in the n−3 PUFA group than in the control group (mean difference: 2.69% (95% CI: 2.23%, 3.14%), which confirmed the EPA bioavailability.

Conclusion: Oral n−3 PUFAs appear to abrogate photoimmunosuppression in human skin, providing additional support for their chemopreventive role; verification of study findings is required.
Avatar de l’utilisateur
Nutrimuscle-Conseils
Forum Admin
 
Messages: 38839
Inscription: 11 Sep 2008 19:11

Retourner vers Actualités, vidéos, études scientifiques

Qui est en ligne

Utilisateurs parcourant ce forum: Bing [Bot] et 2 invités