même en combinaison avec une alimentation hyperprotéinée
Creatine Supplementation Does Not Affect Measured Renal Function In Resistance Trained Subjects: A Pilot Study
Rebeca Lugaresi Medicine & Science in Sports & Exercise. 2012 44(5S): p 606
A growing number of human studies have reported the safety of creatine supplementation on estimated glomerular filtration rate (GFR) (e.g., creatinine clearance). However, there is a paucity
of data on the effect of creatine supplementation in measured GFR in subjects ingesting a high-protein intake.
PURPOSE: To investigate the effects of creatine supplementation on measured GFR in resistance trained subjects ingesting a high-protein diet (ranging from 1.2 to 10.7 g/Kg BW/day).
METHODS: A 12-week randomized, double-blind, placebo-controlled
trial was conducted. Fifteen resistance trained males were randomly assigned to either the creatine (CR) or the placebo (PL) group. The CR group (n =8) received 20g/day of creatine for five
days followed by
5g/day throughout the study. The PL group (n =7) received the same amount of dextrose. At baseline (PRE) and after 12 weeks of intervention (POST), 51Cr-EDTA clearance, creatinine
clearance, serum and urinary sodium and potassium, urea urinary, albuminuria and proteinuria were assessed. Food intake was assessed by a 7-day food record.
RESULTS: 51Cr-EDTA clearance was unchanged within and between groups (PRE
CR: 101.31 ± 14.37, PL: 106.51 ± 20.57; POST CR: 104.61 ± 14.45, PL: 97.3 ± 17.05 mL/min/1,733). Protein intake was similar between groups and did not change throughout the study (PRE
CR: 1.8 ± 0.8, PL: 1,7 ± 0,3; POST CR: 1.6 ± 0.9, PL: 1.4 ± 0.6 g/kg bw/day). Creatinine clearance was also comparable between groups before and after the supplementation (PRE CR: 2.2 ±
0.5 PL: 1.6 ± 0.7, POST CR: 2.41 ± 0.33, PL: 2.1 ± 0.6 g/vol 24h). Additionally, serum creatinine, proteinuria, urinary and serum sodium and potassium, urea urinary and albuminuria remained
stable and within normal range in both groups.
CONCLUSION: Creatine supplementation did not affect measured GFR or any other parameter of kidney function in resistance-trained subjects ingesting a high-protein diet, further
confirming that this supplement is safe to the kidneys. Future studies should investigate whether this holds true in a long-term basis.