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The sulfated polysaccharides are considered as a promising antiviral drug in the future. The diverse structure of SPs has an essential role in boosting the host antiviral response by interfering with virus attachment, adsorption, and its replication process. There are several antiviral studies of marine polysaccharides have been performed in vitro or on specific animal models. Across 40 compounds are commercially available in the market, and many more are being implemented at the preclinical or clinical stages of human trials. More initiatives are required to study the chemical composition, biological potency, and associated mechanisms of SPs in pharmaceutical sectors.