Effect of high dose vitamin D supplementation in combination with weight loss diet on Glucose homeostasis, insulin resistance and matrix metalloproteinases in obese subjects with vitamin D deficiency: a double blind placebo-controlled randomized clinical trial
Soodabeh Aliashrafi, Physiologie appliquée, nutrition et métabolisme December 2019.
As there is limited and inconsistent evidence in potential role of vitamin D on insulin resistance and matrix metalloproteinases, this study aimed to examine the effect of vitamin D supplementation on glucose homeostasis, insulin resistance and matrix metalloproteinases in obese subjects with vitamin D deficiency.
A total of 44 participants with serum 25(OH)D level ≤ 50 nmol/L and body mass index (BMI) 30-40 kg/m2 were randomly allocated into receiving weight reduction diet with either 50000 IU vitamin D3 pearl (n = 22) or placebo (n = 22) once weekly for 12 weeks. Primary outcomes were changes in fasting serum glucose (FSG), homeostasis model assessment insulin resistance (HOMA-IR), quantitative insulin sensitivity check index (QUICKI) and matrix metalloproteinases (MMPs). Secondary outcomes were changes in weight, body mass index (BMI), 25(OH) D, calcium, phosphorous and Parathyroid hormone (PTH). Sun exposure and dietary intakes were also assessed. Serum levels of 25(OH) D3 increased significantly with a simultaneous decrease in serum concentration of PTH in vitamin D group. Weight, BMI, FSG and MMP-9 decreased significantly in both groups; while there were found significant differences in changes in weight, serum 25(OH) D3, PTH and MMP-9 levels between the groups. Within and between groups analysis revealed no significant differences in serum calcium, phosphorous, serum insulin, HOMA-IR, QUICKI and MMP-2 after intervention.
Our results indicated that improvement in vitamin D status resulted in greater reductions in weight and MMP-9 during weight loss. These preliminary results are sufficient to warrant a bigger study group.
