Single dose administration of L-carnitine improves antioxidant activities in healthy subjects
Cao Y, Qu HJ, Tohoku J Exp Med, 2011; 224(3): 209-13.
In a study involving 12 healthy subjects, supplementation with liquid L-carnitine (2.0 g) as a single dose was found to be associated with increases in the activities of antioxidant enzymes and total antioxidant capacity (TAC). Specifically, a gradual increase in plasma concentrations of superoxide dismutase, gluatathione peroxidase, catalase, and total antioxidative capacity in the 3.5 hours following L-carnitine administration was found, and plasma concentrations of SOD, GSH-Px, catalase, and T-AOC returned to baseline within 24 hours. A positive association was found between L-carnitine concentration and the antioxidant index of SOD, GSH-Px, catalase, or T-AOC.L-carnitine increases activities of antioxidant enzymes and the total antioxidant capacity in healthy subjects. It may be useful as a supplementary therapy for chronic illnesses involving excessive oxidative stress."
