The effect of ageing on the resolution of inflammation
Wezi Sendama Ageing Research Reviews Volume 57, January 2020
Highlights
• Age-related chronic inflammation (inflammaging) contributes to diseases of ageing.
• Inflammaging suggests age-associated impairment of the resolution of inflammation.
• Human models of inflammation in ageing will be useful in defining these defects.
Ageing is associated with the development of a low-level, systemic, chronic inflammation known as “inflammaging”. This chronic inflammatory state can contribute to diseases of ageing such as sarcopenia and frailty. The presence of inflammaging suggests a failure of the cell clearance mechanisms that ordinarily aid in the resolution of inflammation after pathogen infiltration or tissue injury. This review aims to explore what is known of how the processes involved in the resolution of inflammation might become defective with age.
