Curcuma: la science a t'elle tout faux?

[Nutrimuscle-Conseils]

The Essential Medicinal Chemistry of Curcumin
Journal of Medicinal Chemistry January 11, 2017 Kathryn M. Nelson

Curcumin is a constituent (up to ∼5%) of the traditional medicine known as turmeric. Interest in the therapeutic use of turmeric and the relative ease of isolation of curcuminoids has led to their extensive investigation. Curcumin has recently been classified as both a PAINS (pan-assay interference compounds) and an IMPS (invalid metabolic panaceas) candidate. The likely false activity of curcumin in vitro and in vivo has resulted in >120 clinical trials of curcuminoids against several diseases. No double-blinded, placebo controlled clinical trial of curcumin has been successful. This manuscript reviews the essential medicinal chemistry of curcumin and provides evidence that curcumin is an unstable, reactive, nonbioavailable compound and, therefore, a highly improbable lead. On the basis of this in-depth evaluation, potential new directions for research on curcuminoids are discussed.

[Nutrimuscle-Diététique]

Traduction de l’étude

La chimie médicinale essentielle de la curcumine
Journal of Medicinal Chemistry 11 janvier 2017 Kathryn M. Nelson

La curcumine est un constituant (jusqu'à ~ 5%) de la médecine traditionnelle connue sous le nom de curcuma. L'intérêt de l'utilisation thérapeutique du curcuma et la relative facilité d'isolement des curcuminoïdes a conduit à une enquête approfondie. La curcumine a récemment été classée à la fois comme PAINS (pan-assay interference compounds) et IMPS (invalid metabolic panaceas) . La fausse activité probable de la curcumine in vitro et in vivo a entraîné plus de 120 essais cliniques de curcuminoïdes contre plusieurs maladies. Aucun essai clinique en double aveugle contrôlé par placebo sur la curcumine n'a été un succès. Ce manuscrit examine la chimie médicinale essentielle de la curcumine et fournit des preuves que la curcumine est un composé instable, réactif, non biodisponible. Sur la base de cette évaluation approfondie, de nouvelles orientations possibles pour la recherche sur les curcuminoïdes sont discutées.

[Nutrimuscle-Conseils]

toujours d'actualité

[audiomaniac]

Il existe des formes hautement assimilable

[Nutrimuscle-Conseils]

rien à voir avec ce qui est expliquée ici
et ton assimilation... qui le dit à part le fabriquant?

[audiomaniac]

https://www.ncbi.nlm.nih.gov/pubmed/21413691

[audiomaniac]

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