Sleep extension increases IGF-I concentrations before and during sleep deprivation in healthy young men
MOUNIR CHENNAOUI Physiologie appliquée, nutrition et métabolisme 2016. May
Sleep deprivation is known to suppress circulating trophic factors such as IGF-I and BDNF. This experiment examined the effect of an intervention involving 6 nights of extended sleep before total sleep deprivation on this catabolic profile. In a randomized cross-over design, 14 young men (age range: 26-37 years) were either in extended (EXT) or habitual (HAB) sleep condition (21:00 - 07:00 or 22:30 - 07:00, time in bed), followed by three days in the laboratory with blood sampling at baseline (B), after 24 h of sleep deprivation (24h-SD), and after one night of recovery sleep (R).
Under EXT compared to HAB, free IGF-I levels were significantly higher at B, 24h-SD and R (P<0.001), and those of total IGF-I at B and 24h-SD (P<0.05). EXT did not influence GH, IGFBP-3, BDNF, insulin and glucose levels. The only one effect of 24 h of sleep deprivation was for insulin levels that are significantly higher after R compared to B.
In healthy adult, additional sleep over one week increased blood concentrations of the anabolic factor IGF-I before and during 24 hours of sleep deprivation and after the subsequent recovery night without effects on BDNF. With further research, these findings may prove to be important in guiding effective lifestyle modifications to limit physical or cognitive deficits associated with IGF-I declines with age.
