Lactobacillus-fermented milk enhances postprandial muscle protein synthesis in Sprague-Dawley rats
Koichiro Sumi Journal of Functional Foods Volume 66, March 2020, 103789
Highlights
• Fermented milk produced larger increase in plantaris MPS than skim and acidified milk.
• Rats given fermented or acidified milk absorbed AA faster than rats given skim milk.
• PPI treatment reduced AA absorption, but not MPS after fermented milk ingestion.
This study aimed to investigate the effects of Lactobacillus-fermented milk on postprandial skeletal muscle protein synthesis (MPS) in rats. Within 4 h of administration, bulk and time-specific fractional MPS were measured using deuterium and the tracer D5-phenylalanine, respectively. Both bulk and fractional MPS were higher for the group given fermented milk compared to the groups given skim or acidified milk (Bulk P = 0.08 and 0.06 vs. skim and acidified milk, respectively; Fractional: P < 0.01 vs. Skim and P = 0.06 vs. Acidified by two-way analysis of variance (ANOVA)). Treatment with a proton pump inhibitor (PPI), which was used to elucidate the impact of acidic pH, did not significantly affect fractional MPS, although PPI did decrease leucine absorption in the Fermented milk group. These results suggested that fermented milk enhanced postprandial MPS via pH-independent mechanisms.