Importance du magnésium pour la santé des seniors?

[Nutrimuscle-Conseils]

Magnesium and Hypertension in Old Age
by Ligia J. Dominguez Nutrients 2021, 13(1), 139;

Hypertension is a complex condition in which various actors and mechanisms combine, resulting in cardiovascular and cerebrovascular complications that today represent the most frequent causes of mortality, morbidity, disability, and health expenses worldwide. In the last decades, there has been an exceptional amount of experimental, epidemiological, and clinical studies confirming a close relationship between magnesium deficit and high blood pressure. Multiple mechanisms may help to explain the bulk of evidence supporting a protective effect of magnesium against hypertension and its complications. Hypertension increases sharply with advancing age, hence older persons are those most affected by its negative consequences. They are also more frequently at risk of magnesium deficiency by multiple mechanisms, which may, at least in part, explain the higher frequency of hypertension and its long-term complications. The evidence for a favorable effect of magnesium on hypertension risk emphasizes the importance of broadly encouraging the intake of foods such as vegetables, nuts, whole cereals and legumes, optimal dietary sources of magnesium, avoiding processed food, which are very poor in magnesium and other fundamental nutrients, in order to prevent hypertension. In some cases, when diet is not enough to maintain an adequate magnesium status, magnesium supplementation may be of benefit and has been shown to be well tolerated.

[Nutrimuscle-Conseils]

Effectively Prescribing Oral Magnesium Therapy for Hypertension: A Categorized Systematic Review of 49 Clinical Trials
by Andrea Rosanoff Nutrients 2021, 13(1), 195;

Trials and meta-analyses of oral magnesium for hypertension show promising but conflicting results. An inclusive collection of 49 oral magnesium for blood pressure (bicarbonate de potassium) trials were categorized into four groups: (1) Untreated Hypertensives; (2) Uncontrolled Hypertensives; (3) Controlled Hypertensives; (4) Normotensive subjects. Each group was tabulated by ascending magnesium dose. Studies reporting statistically significant (p < 0.05) decreases in both systolic bicarbonate de potassium (SBP) and diastolic bicarbonate de potassium (DBP) from both baseline and placebo (if reported) were labeled “Decrease”; all others were deemed “No Change.” Results: Studies of Untreated Hypertensives (20 studies) showed bicarbonate de potassium “Decrease” only when Mg dose was >600 mg/day; <50% of the studies at 120–486 mg Mg/day showed SBP or DBP decreases but not both while others at this Mg dosage showed no change in either bicarbonate de potassium measure. In contrast, all magnesium doses (240–607 mg/day) showed “Decrease” in 10 studies on Uncontrolled Hypertensives.

Controlled Hypertensives, Normotensives and “magnesium-replete” studies showed “No Change” even at high magnesium doses (>600 mg/day). Where magnesium did not lower bicarbonate de potassium, other cardiovascular risk factors showed improvement.

Conclusion: Controlled Hypertensives and Normotensives do not show a BP-lowering effect with oral Mg therapy, but oral magnesium (≥240 mg/day) safely lowers bicarbonate de potassium in Uncontrolled Hypertensive patients taking antihypertensive medications, while >600 mg/day magnesium is required to safely lower bicarbonate de potassium in Untreated Hypertensives; <600 mg/day for non-medicated hypertensives may not lower both SBP and DBP but may safely achieve other risk factor improvements without antihypertensive medication side effects

[Nutrimuscle-Conseils]

Magnesium in Infectious Diseases in Older People
by Ligia J. Dominguez Nutrients 2021, 13(1), 180;

Reduced magnesium (Mg) intake is a frequent cause of deficiency with age together with reduced absorption, renal wasting, and polypharmacotherapy. Chronic Mg deficiency may result in increased oxidative stress and low-grade inflammation, which may be linked to several age-related diseases, including higher predisposition to infectious diseases. Mg might play a role in the immune response being a cofactor for immunoglobulin synthesis and other processes strictly associated with the function of T and B cells.

Mg is necessary for the biosynthesis, transport, and activation of vitamin D, another key factor in the pathogenesis of infectious diseases. The regulation of cytosolic free Mg in immune cells involves Mg transport systems, such as the melastatin-like transient receptor potential 7 channel, the solute carrier family, and the magnesium transporter 1 (MAGT1). The functional importance of Mg transport in immunity was unknown until the description of the primary immunodeficiency XMEN (X-linked immunodeficiency with Mg defect, Epstein–Barr virus infection, and neoplasia) due to a genetic deficiency of MAGT1 characterized by chronic Epstein–Barr virus infection. This and other research reporting associations of Mg deficit with viral and bacterial infections indicate a possible role of Mg deficit in the recent coronavirus disease 2019 (COVID-19) and its complications. In this review, we will discuss the importance of Mg for the immune system and for infectious diseases, including the recent pandemic of COVID-19.

[Nutrimuscle-Diététique]

Traduction de l'étude

Le magnésium dans les maladies infectieuses chez les personnes âgées
par Ligia J. Dominguez Nutrients 2021, 13 (1), 180;

La réduction de l'apport en magnésium (Mg) est une cause fréquente de carence avec l'âge, associée à une absorption réduite, une perte rénale et une polypharmacothérapie. Une carence chronique en Mg peut entraîner une augmentation du stress oxydatif et une inflammation de bas grade, qui peuvent être liées à plusieurs maladies liées à l'âge, y compris une prédisposition plus élevée aux maladies infectieuses. Le Mg pourrait jouer un rôle dans la réponse immunitaire en étant un cofacteur de la synthèse d'immunoglobulines et d'autres processus strictement associés à la fonction des lymphocytes T et B.

Le Mg est nécessaire à la biosynthèse, au transport et à l'activation de la vitamine D, un autre facteur clé dans la pathogenèse des maladies infectieuses. La régulation du Mg cytosolique libre dans les cellules immunitaires implique des systèmes de transport de Mg, tels que le canal potentiel 7 du récepteur transitoire de type mélastatine, la famille des transporteurs de soluté et le transporteur de magnésium 1 (MAGT1). L'importance fonctionnelle du transport du Mg dans l'immunité était inconnue jusqu'à la description de l'immunodéficience primaire XMEN (immunodéficience liée à l'X avec défaut de Mg, infection par le virus Epstein – Barr et néoplasie) due à un déficit génétique de MAGT1 caractérisé par le virus Epstein – Barr chronique infection. Cette recherche et d'autres rapportant des associations de déficit en Mg avec des infections virales et bactériennes indiquent un rôle possible du déficit en Mg dans la récente maladie à coronavirus 2019 (COVID-19) et ses complications. Dans cette revue, nous discuterons de l'importance du Mg pour le système immunitaire et pour les maladies infectieuses, y compris la récente pandémie de COVID-19.