The Acute Effects Of Pre-exercise Glucose Ingestion On Respiratory Quotient, Carbohydrate, And Lipid Oxidation Rates In Overweight/obese Adults
Atencio-Osorio, Medicine & Science in Sports & Exercise: August 2021 - Volume 53 - Issue 8S - p 237
PURPOSE: To examine the acute effects of pre-exercise ingestion of a concentrated glucose solution on respiratory quotient [RQ], carbohydrate, and lipid oxidation rates in overweight/obese adults.
METHODS: Twenty-four (32.8 ± 8.3 yr) overweight/obese (BMI 28.6 ± 3.4 kg/m2) and body fat (32.3 ± 6.8 %) adults were measured on two occasions separated by at least 1 week. Sprint interval training consisted of 8 × 30-second sprints "all out" efforts on a cycle ergometer adjusted individually to a workload of 0.075% watt/kg of muscle mass. On both days, the subjects were overnight fasted, and control and/or exercise were performed in the morning (07.00 AM). The glucose drink consisted of 75 g glucose, 100 ml of an orange-flavoured liquid. Carbon dioxide [CO2] production and oxygen [O2] consumption were measured by indirect calorimetry (Q-NRG® calorimeter, Cosmed, Italy) in the supine position to calculate resting and postprandial energy expenditure [EE] and RQ = [VCO2/VO2]. Blood samples and indirect calorimetry parameters were drawn from a capillary blood sample before and immediately after glucose drink and control/exercise and during a 3-hour recovery phase at the following time points: +0, +60 post 75 g glucose, +90, +120 and + 180 min. Incremental area under the curve (iAUC) was calculated from the time points.
RESULTS: RQ increased similarly within the first 60 min after 75 g glucose drink ingestion. Then, RQ rather continued to increase within the next 1 h to 3 h recovery min in controls, whereas it started to decrease in SIT group (iAUC240min = 194.2 ± 10.5 vs. 187.4 ± 12.2, p = 0.030). At all postprandial time points, iAUC values were significantly higher in SIT vs. control group, indicating lower postprandial carbohydrate oxidation rates (difference means iAUC240min = 2172.0 ± 948.6, p = 0.025) and, therefore, higher lipid oxidation rates (difference means iAUC240min = 2109.0 ± 972.6, p = 0.034).
CONCLUSIONS: We found that ingesting 75 g of glucose 60 min before SIT protocol increased the rate of fat oxidation and decreased carbohydrate oxidation rate. In addition, the SIT intervention at which the lower of RQ levels is observed decreased significant (control group difference means iAUC240min = -6.7 ± 3.0, p = 0.030).