n'abaissent pas leur puissance anabolique
(The FASEB Journal. 2013;27:249.6)
Carbohydrate co-ingestion with protein delays dietary protein digestion and absorption but does not modulate postprandial muscle protein accretion
Stefan H Gorissen
We determined the impact of carbohydrate co-ingestion with protein on dietary protein digestion and absorption kinetics and postprandial muscle protein accretion in healthy men. Twenty-four young (age: 21±1 y, BMI: 21.8±0.5 kg/m2) and 24 older (age: 75±1 y, BMI: 25.4±0.6 kg/m2) men received a primed continuous L-[ring-2H5]-phenylalanine infusion and ingested 20 g L-[1-13C]- phenylalanine-labeled protein with (PRO+CHO) or without (PRO) 60 g carbohydrate. Biopsies were collected from the vastus lateralis. Carbohydrate co-ingestion delayed the rise in exogenous phenylalanine appearance rate (P<0.05). Dietary protein-derived phenylalanine availability over the postprandial period was lower in the old (60±2%) when compared with the young (72±2%; P<0.05), with no differences between the PRO and PRO+CHO condition (P=0.42). Carbohydrate co-ingestion did not modulate postprandial muscle protein synthesis rates (0.035±0.003 vs 0.043±0.004 and 0.033±0.002 vs 0.035±0.003 %/h following PRO vs PRO+CHO in the young and old, respectively). In accordance, no differences in muscle protein-bound L-[1-13C]-phenylalanine enrichments were observed between groups (0.020±0.003 vs 0.018±0.003 and 0.017±0.003 vs 0.022±0.004 MPE following PRO vs PRO+CHO in the young and old, respectively). We conclude that carbohydrate co-ingestion does not modulate postprandial muscle protein accretion in young or older men.