Targeting neuroinflammation, the therapeutic potential of omega-3 PUFAs in substance abuse
Zhe Shi Nutrition Available online 10 November 2020,
Highlights
• Findings from both our and other laboratories suggest that ω-3 PUFAs are effectively in treating neuroinflammation related mental diseases, and indicate that they could exert positive effects in treating drug addiction.
• In the present short reviews, we summarized and evaluated recently published articles reporting the neuroinflammation mechanism in drug addiction and the immune regulation ability of ω-3 PUFAs, and sought to identify some of the challenges ahead in the translation of ω-3 PUFAs into addiction treatment.
Substance abuse is a chronic relapsing disorder that results in serious health and socioeconomic issues around the world. Addictive drugs induced long-lasting morphological and functional changes in brain circuits have been demonstrated to account for the formation of compulsive drug seeking and taking behavior. Yet, there still lacks reliable therapy. In recent years, accumulating evidence indicated that neuroinflammation was implicated in the development of drug addiction. Findings from both our and other laboratories suggest that ω-3 PUFAs are effectively in treating neuroinflammation related mental diseases, and indicate that they could exert positive effects in treating drug addiction. Thus, in the present short reviews, we summarized and evaluated recently published articles reporting the neuroinflammation mechanism in drug addiction and the immune regulation ability of ω-3 PUFAs, and sought to identify some of the challenges ahead in the translation of ω-3 PUFAs into addiction treatment.
