L'étude en question :
Low Protein Intake Is Associated with a Major Reduction in IGF-1, Cancer, and Overall Mortality in the 65 and Younger but Not Older PopulationMorgan E. Levine et al.
Cell Metabolism, Volume 19, Issue 3, 407-417, 4 March 2014Highlights High protein intake is linked to increased cancer, diabetes, and overall mortality
High IGF-1 levels increased the relationship between mortality and high protein
Higher protein consumption may be protective for older adults
Plant-derived proteins are associated with lower mortality than animal-derived proteins
SummaryMice and humans with growth hormone receptor/IGF-1 deficiencies display major reductions in age-related diseases. Because protein restriction reduces GHR-IGF-1 activity, we examined links between protein intake and mortality. Respondents aged 50–65 reporting high protein intake had a 75% increase in overall mortality and a 4-fold increase in cancer death risk during the following 18 years. These associations were either abolished or attenuated if the proteins were plant derived. Conversely, high protein intake was associated with reduced cancer and overall mortality in respondents over 65, but a 5-fold increase in diabetes mortality across all ages. Mouse studies confirmed the effect of high protein intake and GHR-IGF-1 signaling on the incidence and progression of breast and melanoma tumors, but also the detrimental effects of a low protein diet in the very old. These results suggest that low protein intake during middle age followed by moderate to high protein consumption in old adults may optimize healthspan and longevity.
L'étude complète (PDF)