Les vitamines K pour la santé générale?

[Nutrimuscle-Conseils]

The Role of Vitamin K in Humans: Implication in Aging and Age-Associated Diseases
by Daniela-Saveta Popa Antioxidants 2021, 10(4), 566;

As human life expectancy is rising, the incidence of age-associated diseases will also increase. Scientific evidence has revealed that healthy diets, including good fats, vitamins, minerals, or polyphenolics, could have antioxidant and anti-inflammatory activities, with antiaging effects. Recent studies demonstrated that vitamin K is a vital cofactor in activating several proteins, which act against age-related syndromes. Thus, vitamin K can carboxylate osteocalcin (a protein capable of transporting and fixing calcium in bone), activate matrix Gla protein (an inhibitor of vascular calcification and cardiovascular events) and carboxylate Gas6 protein (involved in brain physiology and a cognitive decline and neurodegenerative disease inhibitor).

By improving insulin sensitivity, vitamin K lowers diabetes risk. It also exerts antiproliferative, proapoptotic, autophagic effects and has been associated with a reduced risk of cancer. Recent research shows that protein S, another vitamin K-dependent protein, can prevent the cytokine storm observed in COVID-19 cases. The reduced activation of protein S due to the pneumonia-induced vitamin K depletion was correlated with higher thrombogenicity and possibly fatal outcomes in COVID-19 patients. Our review aimed to present the latest scientific evidence about vitamin K and its role in preventing age-associated diseases and/or improving the effectiveness of medical treatments in mature adults ˃50 years old.

[Nutrimuscle-Conseils]

Consumption of Vitamin K and Vitamin A Are Associated With Reduced Risk of Developing Emphysema: NHANES 2007-2016
Tianjiao Shen Front Nutr. 2020 Apr 21;7:47.

Chronic obstructive pulmonary disease (COPD) comprising of emphysema and chronic bronchitis are the most common chronic respiratory diseases that impart a huge economic and clinical burden. Factors other than smoking and air pollutants can cause inflammation and emphysematous changes in the lung airspaces or alveoli have been understudied. Using a cross-sectional study design, we assessed the association of dark green vegetables, vitamin K and Vitamin A with emphysema status among adults at U.S. These nutrients have a role in lung biology.

A complete case NHANES data (n = 17,681) was used. After adjusting for modifiable and non-modifiable confounders, consumption of recommended amounts of vitamin K was associated with 39% decrease in odds (Odds Ratio: 0.61; 95% CI: 0.40-0.92, P-val: 0.02) of emphysema. Similarly consumption of recommended amounts vitamin A dose was associated with 33% decrease in odds (Odds Ratio: 0.67; 95% CI: 0.44-1.00, P-val: 0.05) of emphysema. Vitamin K shows an inverse association suggesting that it may be important in slowing the emphysematous process. Vitamin A is important in maintaining the anti-inflammatory process. Together vitamin K and vitamin A are important in the lung health.

[Nutrimuscle-Diététique]

Traduction de l'étude

La consommation de vitamine K et de vitamine A est associée à une réduction du risque de développer un emphysème: NHANES 2007-2016
Tianjiao Shen Front Nutr. 21 avril 2020; 7:47.

La maladie pulmonaire obstructive chronique (MPOC) comprenant l'emphysème et la bronchite chronique sont les maladies respiratoires chroniques les plus courantes qui représentent un énorme fardeau économique et clinique. Des facteurs autres que le tabagisme et les polluants atmosphériques peuvent provoquer une inflammation et des changements emphysémateux dans les espaces aériens pulmonaires ou les alvéoles ont été sous-étudiés. À l'aide d'un plan d'étude transversal, nous avons évalué l'association des légumes vert foncé, de la vitamine K et de la vitamine A avec le statut d'emphysème chez les adultes aux États-Unis.Ces nutriments jouent un rôle dans la biologie pulmonaire.

Un cas complet de données NHANES (n = 17 681) a été utilisé. Après ajustement pour tenir compte des facteurs de confusion modifiables et non modifiables, la consommation des quantités recommandées de vitamine K était associée à une diminution de 39% des cotes (rapport de cotes: 0,61; IC à 95%: 0,40-0,92, P-val: 0,02) de l'emphysème. De même, la consommation de doses recommandées de vitamine A était associée à une diminution de 33% des cotes (rapport de cotes: 0,67; IC à 95%: 0,44-1,00, P-val: 0,05) de l'emphysème. La vitamine K montre une association inverse suggérant qu'elle peut être importante pour ralentir le processus emphysémateux. La vitamine A est importante pour maintenir le processus anti-inflammatoire. Ensemble, la vitamine K et la vitamine A sont importantes pour la santé pulmonaire.