Dietary vs. pharmacological doses of zinc: A clinical review
Heitor O. Santos clin nutr May 2020Volume 39, Issue 5, Pages 1345–1353
Highlights
•Zinc status is of primary importance across the human lifespan.
•Zinc deficiencies are a health concern in both developing and developed countries.
•Zinc mediates anti-inflammatory and antioxidant pathways.
•A pharmacological dosage of zinc can be beneficial to avoid nutritional imbalances.
•Few side effects are linked to medical dosages of zinc.
Zinc deficiency has a global impact on health in both developing and developed countries, especially among children and the elderly. By modulating anti-inflammatory and antioxidant pathways, zinc supplementation is recommended for the treatment of several ailments, such as liver disease, male hypogonadism, cancers, heart disease (e.g. dyslipidemia) and central nervous system disorders; however, the topic of dietary vs. pharmacological doses of zinc remains controversial. This paper provides a detailed critical review of the effects of zinc supplementation in medicinal doses (i.e. >40 mg/d of elemental zinc) on human health. We further highlight the difficulty in achieving a therapeutic dose of zinc from foodstuffs.