ω-3 marins sur le risque d'adénomes colorectaux et polypes?

[Nutrimuscle-Conseils]

Effect of Supplementation With Marine ω-3 Fatty Acid on Risk of Colorectal Adenomas and Serrated Polyps in the US General Population
A Prespecified Ancillary Study of a Randomized Clinical Trial
Mingyang Song JAMA Oncol. Published online November 21, 2019.

Key Points
Question Does marine ω-3 fatty acid supplementation reduce risk of colorectal cancer precursors in the US general population?

Findings In this randomized clinical trial that included 25 871 adults, daily supplementation of marine ω-3 fatty acid, 1 g, did not reduce risk of conventional adenomas or serrated polyps. A suggestive beneficial association was observed among individuals with low plasma levels of ω-3 fatty acid at baseline and among African American persons.

Meaning Daily supplementation with marine ω-3 fatty acids, 1 g, appears not to reduce the risk of colorectal premalignant lesions in the average-risk US population; however, individuals with low plasma levels of ω-3 or African American persons may benefit.

[Nutrimuscle-Diététique]

Effet de la supplémentation en acide gras marin ω-3 marin sur le risque d'adénomes colorectaux et de polypes en dents de scie dans la population générale américaine
Étude auxiliaire préspécifiée d'un essai clinique randomisé
Mingyang Song JAMA Oncol. Publié en ligne le 21 novembre 2019.

Points clés
Question
La supplémentation en acides gras marins en-3 réduit-elle le risque de précurseurs du cancer colorectal dans la population générale des États-Unis?

Résultats
Dans cet essai clinique randomisé comprenant 25 871 adultes, la supplémentation quotidienne en acide gras ω-3 marin, 1 g, n'a pas réduit le risque d'adénomes ou de polypes en dents de scie classiques. Une association bénéfique suggestive a été observée chez les sujets présentant de faibles concentrations plasmatiques d’acides gras-3 au départ et chez les Afro-Américains.

Signification
Une supplémentation quotidienne en acides gras marins ω-3 marins, 1 g, ne semble pas réduire le risque de lésions précancéreuses colorectales dans la population américaine à risque moyen; Cependant, les individus avec de faibles concentrations plasmatiques de ω-3 ou les Afro-américains peuvent en bénéficier.

[Nutrimuscle-Conseils]

Clinical value of serum polyunsaturated fatty acids in patients with gastric polyps
Nan Li Peer J 2024

Polyunsaturated fatty acids (PUFAs) are vital nutrients in human physiology and are implicated in various chronic diseases. However, the relationship between PUFAs and gastric polyps remains unclear. This study employed liquid chromatography-tandem mass spectrometry (LC-MS/MS) to assess PUFA levels in the serum of 350 patients, along with analyzing the ω-6 to ω-3 ratio.

The results revealed significant differences in the levels of C16:1, C18:1, C18:2, α-C18:3, γ-C18:3, C20:1, C20:4, C20:5, ω-3-C22:5, ω-6-C22:5, and C22:6, as well as ω-6 to ω-3 ratio between the control and gasteic polyp groups. Moreover, setting the threshold for ω-6: ω-3 at 10 revealed a close correlation between polyp occurrence and this ratio. These findings suggest that PUFAs and the ω-6 to ω-3 ratio hold promise as potential early screening markers for gastric polyps. However, further research is imperative to elucidate the underlying mechanisms and therapeutic potential of PUFAs in managing gastric polyps.