Un multi-vitamines-minéraux pour éliminer l'arsenic ?

[Nutrimuscle-Conseils]

[Effect of a four-week vitamin and mineral supplementation on the nutritional status and urinary excretion of arsenic in adolescents]
Nutr Hosp. 2018 Jun 22;35(4):894-902. Rebeca Monroy Torres

Introduction: adequate nutrition in adolescence is important for growth and development. There are environmental factors that cannot be avoided, such as exposure to heavy metals through natural sources such as water. Arsenic is a metalloid that can cause damage to health (alterations in nutritional status, diabetes, cancer) and it has been found in concentrations higher than those allowed in drinking water.

Objective: to measure the effect of vitamin and mineral supplementation on the nutritional status and urinary excretion of arsenic in adolescents exposed to this metal through drinking water.

Material and methods: an observational, follow-up study of a cohort was conducted to assess the efficacy of vitamin and mineral supplementation on supplementation in 45 adolescents exposed to arsenic in drinking water, who were given a daily multivitamin supplement for four weeks. Weekly nutritional status and arsenic levels in urine and drinking water were evaluated.

Results: the basal nutritional intake was low for proteins, fiber, folic acid, vitamin B2, B6, B12, E, C, selenium and iron, increasing their consumption through the supplement during the intervention and with an increase of approximately 1 g/dl of hemoglobin in all participants. At the end of the intervention, there was an increase in fat-free mass and a decrease in the percentage of body fat. In relation to the urinary excretion of arsenic, the biggest elimination of this metalloid was observed from the first week of intervention (35.91 μg/g Cr [IC 95% = 23.2-74.8 μg/g Cr]), which was statistically significant compared to basal levels of urinary arsenic (43.2 μg/g Cr [IC 95% = 30.8-117.6 μg/g Cr]) (p < 0.05), with an average water consumption with As of 96.2 ± 7.5 μg/l.

Conclusion: four weeks of supplementation with vitamins and minerals in the adolescent population studied improved nutritional status and increased metalloid excretion significantly in the first and second week after intervention.

[Nutrimuscle-Conseils]

Arsenic and weight loss: At a crossroad between lipogenesis and lipolysis
Somayeh Handali Journal of Trace Elements in Medicine and Biology Volume 68, December 2021, 126836

Arsenic is found in soil, food, water and earth crust. Arsenic exposure is associated with chronic diseases such as cancer, cardiovascular disease as well as diabetes. One of complex effects of arsenic is on weight gain or loss. Involvement of arsenic in both weight loss and gain signaling pathways has previously been reported; however, too little attention has been paid to its weight reducing effect. Animal studies exhibited a role of arsenic in weight loss. In this regard, arsenic interference with endocrine system, leptin and adiponectin hormones as well as thermogenesis is more evidence. Apparently, arsenic-induced weight lossis generally meditated by its interaction with thermogenesis. In this review we have discussed the irregularities in metabolic pathways induced by arsenic that can lead to weight loss.

[Nutrimuscle-Diététique]

Traduction de l'étude

Arsenic et perte de poids : à la croisée des chemins entre lipogenèse et lipolyse
Somayeh Handali Journal of Trace Elements in Medicine and Biology Volume 68, décembre 2021, 126836

L'arsenic se trouve dans le sol, les aliments, l'eau et la croûte terrestre. L'exposition à l'arsenic est associée à des maladies chroniques telles que le cancer, les maladies cardiovasculaires ainsi que le diabète. L'un des effets complexes de l'arsenic est la prise ou la perte de poids. L'implication de l'arsenic dans les voies de signalisation de la perte et du gain de poids a déjà été rapportée; Cependant, trop peu d'attention a été accordée à son effet de réduction de poids. Les études animales ont montré un rôle de l'arsenic dans la perte de poids. À cet égard, l'interférence de l'arsenic avec le système endocrinien, les hormones leptine et adiponectine ainsi que la thermogenèse est une preuve supplémentaire. Apparemment, la perte de poids induite par l'arsenic est généralement méditée par son interaction avec la thermogenèse. Dans cette revue, nous avons discuté des irrégularités des voies métaboliques induites par l'arsenic qui peuvent entraîner une perte de poids.