https://fr.wikipedia.org/wiki/Mutag%C3%A9n%C3%A8se
Why are there not more herbicide-tolerant crops?
Devine MD1.
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Abstract
Herbicide-tolerant (HT) varieties of corn, soybean, canola (oilseed rape) and cotton have been grown since the mid-1990s, and have been widely adopted by farmers in several countries. HT genes have been inserted into or selected for in many other species, including almost all major crop species in the world and many minor crops and ornamental species. In some cases this has been done specifically to introduce the HT trait, whereas in others the HT gene has been used as a selectable marker (eg the bar gene, conferring glufosinate-ammonium tolerance). However, in very few cases have the HT crops generated been commercialized, despite the weed-control advantages that many such crops would offer. There are several reasons for this, including the high research and development costs associated with developing the new HT crop cultivars, the high cost of obtaining regulatory clearance for the HT crops or products derived from them, international trade issues relating to genetically modified crops, and issues surrounding the expanded herbicide registration for the new use and the potential impact of this on the existing registration status of the herbicide. New HT crops are unlikely to be developed unless they offer a sufficiently large advantage to farmers and a substantial assured market to justify the associated development and regulatory costs
https://www.ncbi.nlm.nih.gov/pubmed/15668961
Taking stock of herbicide-resistant crops ten years after introduction.
Duke SO1.
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Abstract
Since transgenic, bromoxynil-resistant cotton and glufosinate-resistant canola were introduced in 1995, planting of transgenic herbicide-resistant crops has grown substantially, revolutionizing weed management where they have been available. Before 1995, several commercial herbicide-resistant crops were produced by biotechnology through selection for resistance in tissue culture. However, non-transgenic herbicide-resistant crops have had less commercial impact. Since the introduction of glyphosate-resistant soybean in 1996, and the subsequent introduction of other glyphosate-resistant crops, where available, they have taken a commanding share of the herbicide-resistant crop market, especially in soybean, cotton and canola. The high level of adoption of glyphosate-resistant crops by North American farmers has helped to significantly reduce the value of the remaining herbicide market. This has resulted in reduced investment in herbicide discovery, which may be problematic for addressing future weed-management problems. Introduction of herbicide-resistant crops that can be used with selective herbicides has apparently been hindered by the great success of glyphosate-resistant crops. Evolution of glyphosate-resistant weeds and movement of naturally resistant weed species into glyphosate-resistant crop fields will require increases in the use of other herbicides, but the speed with which these processes compromise the use of glyphosate alone is uncertain. The future of herbicide-resistant crops will be influenced by many factors, including alternative technologies, public opinion and weed resistance. Considering the relatively few recent approvals for field testing new herbicide-resistant crops and recent decisions not to grow glyphosate-resistant sugarbeet and wheat, the introduction and adoption of herbicide-resistant crops during the next 10 years is not likely to be as dramatic as in the past 10 years.
https://www.ncbi.nlm.nih.gov/pubmed/15660452