il est donc normal de retrouver une créatinine un peu élevée à l'analyse de sang - ce qui ne voudra pas dire que les reins ne marchent pas bien
Assessment of the Effect of High or Low Protein Diet on the Human Urine Metabolome as Measured by NMR
Nutrients 2012, 4(2), 112-131; Lone G. Rasmussen
The objective of this study was to identify urinary metabolite profiles that discriminate between high and low intake of dietary protein during a dietary intervention. Seventy-seven overweight, non-diabetic subjects followed an 8-week low-calorie diet (LCD) and were then randomly assigned to a high (HP) or low (LP) protein diet for 6 months.
The obtained high correlations firmly establish the validity of the metabolomic approach since urinary nitrogen is a well established biomarker for daily protein consumption. The models showed that trimethylamine-N-oxide (TMAO) is correlated to urinary nitrogen. Furthermore, urinary creatine was found to be increased by the HP diet whereas citric acid was increased by the LP diet. Despite large variations in individual dietary intake, differentiated metabolite profiles were observed at the dietary group-level.