Oxygen cost of exercise hyperpnoea is greater in women compared with men
Dominelli PB, Render JN, Molgat-Seon Y, Foster GE, Romer LM, Sheel AW.
The Journal of Physiology, (2015). Accepted manuscript online: 4 FEB 2015.
Abstract
We compared the oxygen cost of breathing (inline VO2RM) in healthy men and women over a wide range of exercise ventilations (inline VE). Eighteen subjects (9 women) completed four days of testing. First, a step- wise maximal cycle exercise test was completed for the assessment of spontaneous breathing patterns. Next, subjects were familiarized with the voluntary hyperpnoea protocol used to estimate inline VO2RM. During the final two visits, subjects mimicked multiple times (4- 6) the breathing patterns associated with 5- 6 different exercise stages. Each trial lasted 5 min and on- line pressure- and flow- volume loops were superimposed on target loops obtained during exercise to accurately replicate the work of breathing.At ˜55 l min−1 inline VE, inline VO2RM was significantly greater in women. At maximum ventilation, the absolute inline VO2RM was not different (P > 0.05) between the sexes, but represented a significantly greater fraction of whole- body inline VO2 in women (13.8 ± 1.5 vs. 9.4 ± 1.1% inline VO2). During heavy exercise at 92 and 100% inline VO2max, the unit cost of inline V Ewas +0.7 and +1.1 mlO2 l−1 greater in women (P < 0.05). At inline VO2max, men and women who developed expiratory flow limitation had a significantly greater inline VO2RMthan those who did not (435 ± 44 vs. 331 ± 30 mlO2 min−1). In conclusion, women have a greater inline VO2RM for a given inline V E and this represents a greater fraction of whole- body inline VO2. The greater inline VO2RM in women may have implications for the integrated physiological response to exercise.
L'étude complète (PDF)