Steroid vs. Platelet-Rich Plasma in Ultrasound-Guided Sacroi

[audiomaniac]

https://www.ncbi.nlm.nih.gov/pubmed/27677100

[audiomaniac]

4 ans apres l'injection pas de rechute...


https://www.ncbi.nlm.nih.gov/pubmed/27392848

[audiomaniac]

Différence premiere génération et seconde génération de PRP

http://www.ijds.in/article.asp?issn=097 ... ast=Bansal

[audiomaniac]

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3591032/

[audiomaniac]

Qu'est ce que c'est que cette histoire ?

The development of technologies to obtain platelet concentrates lead to the formation of a new kind of fibrin adhesive-concentrated Platelet-rich plasma (cPRP); however, because of legal restrictions on blood handling procedures, another family of platelet concentrate appeared in France-Platelet-rich fibrin (PRF)

[audiomaniac]

Avantage au PRF :

Studies showed PRP has limited potential to stimulate bone regeneration as it releases growth factors quickly, just before the cell outgrowth from the surrounding tissue.[17–19]

It is also been demonstrated that bovine thrombin which is used for PRP preparation may have toxic effects on the body cells.

[audiomaniac]

ADVANCED PRF
Pourquoi le Choukroun’s A-PRF™ ?

De nombreux travaux récents ont montré l’intérêt et la potentialité des cellules blanches dans les phénomènes inflammatoires, avec comme corollaire, une action prépondérante dans les premiers temps de stimulation des cellules ostéoprogénitrices. (Omar &Thomsen, Biomaterials 2012, KAWAZOE T. Cell Transplant. 2012 )

Il était donc normal d’essayer de capter plus de monocytes dans le PRF, afin de le rendre plus actif dans la stimulation des greffes osseuses, mais également de les tourner vers une transformation plus rapide des Monocytes en macrophages afin d’augmenter l’effet de stimulation osseuse.

C’est chose faite avec le A-PRF™ ou Advanced-PRF™.

TOUT LE PROTOCOLE CHANGE !
le tube, la vitesse de centrifugation et le temps de centrifugation.

Les premiers résultats de nos recherches, réalisés au Laboratoire de Clarion Research Group, Pennsylvany university (USA) et au Repair-Lab, Institute of Pathology, Johannes Gutenberg University, Mainz (Allemagne) montrent un relargage de BMP-2 (Bone Morphogenetic Protein) ,BMP- 4 et BMP-7. Ces recherches montrent également une libération plus importante de VEGF.

Le tube spécifique qui a été mis au point à la suite de nos recherches scientifiques et certifié en tant que DM est le tube A-PRF™ +.

Ce tube est le seul autorisé à l’heure actuelle. Les tubes classiques utilisés jusqu’à présent étant des tubes pour analyses biologiques et maintenant non règlementaires. Le tube A-PRF™ + est dorénavant disponible en emballage unitaire stérile (depuis mai 2013)

De nombreuses études scientifiques sont en cours : Les résultats seront publiés prochainement. Mais la présence de BMP en quantité suffisante, assure déjà au A-PRF™ un avenir certain, mettant à disposition des praticiens un produit très puissant pour la reconstruction osseuse et à un prix toujours aussi abordable .

[audiomaniac]

A-PRF contre CGF

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5413460/

[audiomaniac]

Ample evidence has emerged recently on the role of monocytes on the vessels growth and bone regeneration. Monocytes play an important role in vascularization, bone growth and production of VEGF. Monocytes are known to have BMP receptors and recently it was discovered that they produce BMP-2. In an attempt to incorporate the monocytes within the PRF, Choukroun[32] introduced an advanced PRF called A-PRF™. They have discovered earlier soft tissue growth, more release of BMPs, greater and faster vascularization and more cytokine release than conventional PRF.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5434315/

[audiomaniac]

Although successful procedures have been reported extensively using Choukran’s L-PRF, physicians such as O’Connell[54] had raised concern regarding possible health hazard with the particles of silica in the glass tubes. In spite of the fact that the silica particles are sufficiently dense so as to sediment along with the RBC’s, they are small enough so that a fraction of them will remain colloidally suspended in the platelet-poor plasma layers, buffy coat and fibrin and might eventually reach the patient during treatment. In this context a study was done by Dohan Ehrenfest et al[9] in 2010 evaluating the cell composition and 3D organization of L-PRF persuaded by different types of collection tubes (such as glass-coated plastic tubes or dry glass) and compression techniques (soft or forcible) on the final L-PRF-membrane architecture. Authors demonstrated that there was no influence of the type of tested tube on the architecture of this second generation PC. However Tunalı et al[33] in 2014, introduced a new product called T-PRF (Titanium-prepared PRF). The use of titanium tubes for collection and centrifugation instead of glass tubes was established on the hypothesis that titanium may be a more efficient platelet activator than silica, for preparing L-PRF. Based on light, scanning electron and fluorescence microscopy analysis, Tunalı et al[33] concluded that T-PRF has immensely organized network along with a continuous integrity and even the fibrin network was thicker and also it covered larger area.


Je ne pensais pas que le contenant pouvais avoir des conséquences (si j'ai bien compris)

[audiomaniac]

CONCLUSION:
The results from the present study indicate that the various platelet concentrates have quite different release kinetics. The advantage of PRP is the release of significantly higher proteins at earlier time points whereas PRF displayed a continual and steady release of growth factors over a 10-day period. Furthermore, in general, it was observed that the new formulation of PRF (A-PRF) released significantly higher total quantities of growth factors when compared to traditional PRF.

CLINICAL RELEVANCE:
Based on these findings, PRP can be recommended for fast delivery of growth factors whereas A-PRF is better-suited for long-term release.

https://www.ncbi.nlm.nih.gov/pubmed/26809431

[audiomaniac]

Vive la France ...

https://ansm.sante.fr/S-informer/Points ... nformation

[Gerard]

Ça comprend quoi "pratique d’actes à visée esthétique" ? Par exemple dans le cas d'une brulure, j'imagine que c'est considéré comme tel ?

La France et ses fossiles... mais c'est un long sujet.

[audiomaniac]

Perte des cheveux et rides, mais apparement les cliniques privés le font quand même en France.

[audiomaniac]

Comparison of the platelet concentrations obtained in platelet-rich plasma (PRP) between the GPS™ II and GPS™ III systemsComparaison des concentrations plaquettaires obtenues au sein du plasma concentré en plaquettes (PRP) entre les systèmes GPS™ II et GPS™ III

https://www.sciencedirect.com/science/a ... 1410001495