Smoking is associated with increased cartilage loss and persistence of bone marrow lesions over 2 years in community-based individuals.
Rheumatology (Oxford). 2009 Aug 20.
Davies-Tuck ML, Wluka AE, Forbes A, Wang Y, English DR, Giles GG, Cicuttini F.
Objective. To determine whether smoking is related to change in tibial and patella cartilage, and the development or persistence of bone marrow lesions (BMLs) over 2 years in a cohort of middle-aged adults. Methods. Two hundred and seventy-one adult subjects recruited from the Melbourne Collaborative Cohort Study underwent an MRI of their dominant knee at baseline and approximately 2 years later. Cartilage volume and BMLs were determined for both time points. At baseline, subjects also completed a questionnaire about current and past cigarette smoking. Results. Being a 'smoker' (former or current) was associated with increased annual loss of medial but not lateral or patella cartilage volume (medial: difference = 13.4 microl, P = 0.03; lateral difference = 4.86 microl, P = 0.45, patella difference = -2.57 microl, P = 0.79). A relationship between increasing pack-years smoked and increased medial cartilage volume loss was also observed (P = 0.04). Amongst people who had a BML at baseline, BMLs present in 'ever smokers' were 11.4 [95% confidence interval (CI) 1.54, 89.9; P = 0.02] times more likely to persist over 2 years than those present in 'never smokers'. In addition, the relationship between smoking and increased medial cartilage loss for subjects with a BML present at baseline was partially mediated by the persistence of the BMLs over 2 years. Conclusion. This study contributes to the evidence of a detrimental effect of smoking on joint cartilage. Furthermore, it provides a possible mechanism that the association smoking shares with increased cartilage loss may be mediated via smoking impairing the ability for BMLs to resolve.
