https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4045593/The biosynthesis of ligament and tendon matrix molecules was clearly stimulated by FORTIGEL®. The RNA expression and biosynthesis of collagen type I and III statistically significantly increased 1.2 fold to 2.4 fold in comparison to untreated control, respectively. In addition, the synthesis of proteoglycans (versican, decorin), was increased in both Achilles tendons and ligament fibroblasts.
Moreover, a statistically significant increase in the elastin biosynthesis, the most prominent component of ligament matrix, was detected. FORTIGEL® treatment leads to an approximately 50 % higher elastin synthesis compared to the untreated control cells.