La vitamine B12 pour la santé des tendons et des os ?

[Nutrimuscle-Conseils]

Low serum vitamin B12 levels are associated with degenerative rotator cuff tear
Jae Hwa Kim, BMC Musculoskeletal Disorders volume 22, Article number: 364 (2021)

Background
Vitamin B12 (Vit B12) deficiency results in elevated homocysteine levels and interference with collagen cross-linking, which may affect tendon integrity. The purpose of this study was to investigate whether serum Vit B12 levels were correlated with degenerative rotator cuff (RC) tear.

Methods
Eighty-seven consecutive patients with or without degenerative RC tear were enrolled as study participants. Possible risk factors (age, sex, medical history, bone mineral density, and serum chemistries including glucose, magnesium, calcium, phosphorus, zinc, homocysteine, Vitamin D, Vit B12, homocysteine, and folate) were assessed. Significant variables were selected based on the results of univariate analyses, and a logistic regression model (backward elimination) was constructed to predict the presence of degenerative RC tear.

Results
In the univariate analysis, the group of patients with degenerative RC tear had a mean concentration of 528.4 pg/mL Vit B12, which was significantly lower than the healthy control group (627.1 pg/mL). Logistic regression analysis using Vit B12 as an independent variable revealed that Vit B12 concentrations were significantly correlated with degenerative RC tear (p = 0.044). However, Vit B12 levels were not associated with tear size.

Conclusion
Low serum levels of Vit B12 were independently related to degenerative RC tear. Further investigations are warranted to determine if Vit B12 supplementation can decrease the risk of this condition.

[Nutrimuscle-Diététique]

Traduction de l'étude

De faibles taux sériques de vitamine B12 sont associés à une déchirure dégénérative de la coiffe des rotateurs
Jae Hwa Kim, BMC Musculoskeletal Disorders volume 22, numéro d'article: 364 (2021)

Arrière-plan
Une carence en vitamine B12 (vitamine B12) entraîne des niveaux élevés d'homocystéine et une interférence avec la réticulation du collagène, ce qui peut affecter l'intégrité du tendon. Le but de cette étude était de déterminer si les taux sériques de Vit B12 étaient corrélés avec la déchirure dégénérative de la coiffe des rotateurs (RC).

Méthodes
Quatre-vingt-sept patients consécutifs avec ou sans déchirure dégénérative RC ont été recrutés comme participants à l'étude. Les facteurs de risque possibles (âge, sexe, antécédents médicaux, densité minérale osseuse et chimies sériques, y compris le glucose, le magnésium, le calcium, le phosphore, le zinc, l'homocystéine, la vitamine D, la vitamine B12, l'homocystéine et le folate) ont été évalués. Des variables significatives ont été sélectionnées sur la base des résultats d'analyses univariées, et un modèle de régression logistique (élimination rétrograde) a été construit pour prédire la présence d'une déchirure dégénérative RC.

Résultats
Dans l'analyse univariée, le groupe de patients atteints de déchirure dégénérative RC avait une concentration moyenne de 528,4 pg / mL de Vit B12, ce qui était significativement plus faible que le groupe témoin sain (627,1 pg / mL). Une analyse de régression logistique utilisant la vitamine B12 comme variable indépendante a révélé que les concentrations de vitamine B12 étaient significativement corrélées avec la déchirure dégénérative RC (p = 0,044). Cependant, les niveaux de vitamine B12 n'étaient pas associés à la taille des larmes.

Conclusion
De faibles taux sériques de Vit B12 étaient indépendamment liés à une déchirure dégénérative de la RC. Des investigations supplémentaires sont nécessaires pour déterminer si la supplémentation en vitamine B12 peut réduire le risque de cette condition.

[Nutrimuscle-Conseils]

Association between multiple vitamins and bone mineral density: a cross-sectional and population-based study in the NHANES from 2005 to 2006
Ruyi Zhang, BMC Musculoskeletal Disorders volume 24, Article number: 113 (2023)

Background
Bone mineral density (BMD) alterations in response to multivitamin exposure were rarely studied. Our study assessed the association of coexposure to six types of vitamins (i.e., vitamins B12, B9, C, D, A and E) with BMD measurements in adults in the US.

Methods
Data were collected from participants aged ≥ 20 years (n = 2757) in the U.S. National Health and Nutrition Examination Surveys (NHANES) from 2005 to 2006. Multiple linear regression, restricted cubic splines, principal component analysis (PCA) and weighted quantile sum (WQS) regression were performed for statistical analysis.

Results
The circulating levels of vitamins B12 and C were positively associated with BMDs, and an inverted L-shaped exposure relationship was observed between serum vitamin C and BMDs. PCA identified two principal components: one for ‘water-soluble vitamins’, including vitamins B12, B9 and C, and one for ‘fat-soluble vitamins’, including vitamins A, D and E. The former was positively associated with total femur (β = 0.009, 95%CI: 0.004, 0.015) and femoral neck (β = 0.007, 95%CI: 0.002, 0.013) BMDs, and the latter was negatively associated with BMDs with non-statistical significance. The WQS index constructed for the six vitamins was significantly related to total femur (β = 0.010, 95%CI: 0.001, 0.018) and femoral neck (β = 0.008, 95%CI: 0.001, 0.015) BMDs, and vitamins B12 and C weighted the most. The WQS index was inversely related to BMDs with non-statistical significance, and vitamins E and A weighted the most.

Conclusion
Our findings suggested a positive association between water-soluble vitamin coexposure and BMD, and the association was mainly driven by vitamins B12 and C. Negative association between fat-soluble vitamin coexposure and BMD was indicated, mainly driven by vitamins E and A. An inverted L-shaped exposure relationship was found between vitamin C and BMD.