La vitamine C pour la régénération tendineuse?

[Nutrimuscle-Conseils]

Does vitamin C supplementation improve rotator cuff healing? A preliminary study
M Martel Eur J Orthop Surg Traumatol. 2021 Mar 16.

Purpose: One of the complications after rotator cuff repair is a tendon non-healing. It has already been posited in the literature that vitamin C (VC) promotes tendon healing through its antioxidant properties and its role as a cofactor in collagen synthesis. The aim of this study was to evaluate the effect of postoperative VC supplementation on the tendon healing following repair.

Methods: This randomized monocentric prospective study included 98 patients who underwent arthroscopic rotator cuff repair in 1-year period and follow-up ultrasound 6 months postoperatively. The cohort was divided into two groups: the VC+ group (500 mg/day PO for 45 days postoperatively) and the VC- group (no supplementation). The evaluation criterion was tendon healing at 6 months postoperatively according to the Sugaya ultrasound classification. Preoperative and postoperative clinical evaluations were based on active mobilities, the Constant score and the subjective shoulder value.

Results: There was no difference in term of postoperative outcomes between the two groups. At an average follow-up of 6.3 months, the non-healing rate in the overall population was 17%. This rate was higher in VC- compared to VC+, respectively, 23% vs. 11%), p = 0.2.

Conclusion: This study showed a trend to improve tendon healing after rotator cuff repair with VC supplementation. However, a prospective study with a larger patient population should be conducted to confirm this finding.

[Nutrimuscle-Conseils]

Vitamin C in orthopedic practices: Current concepts, novel ideas, and future perspectives
Bennett Oakes J Ortho Res 10 December 2020

Vitamin C (ascorbic acid), is an important antioxidant that has been applied broadly in the field of orthopaedics. Current research on vitamin C examines the molecule's role in bone and tendon physiology, as well as joint replacement and Postoperative pain.

Most laboratory and human studies associate the use of vitamin C with improved bone health and tendon healing. Recent literature moderately supports the use of vitamin C to improve functional outcomes, decreased postoperative pain, and prevent complex regional pain syndrome following orthopaedic procedures. The perioperative use of vitamin C in patients undergoing joint replacement surgery and anterior cruciate ligament reconstruction is still under investigation. Overall, there is need for high‐quality human trials to confirm whether vitamin C can potentiate the outcomes of orthopaedic procedures and to determine optimal dosage and means of administration to maximize its proposed benefits. The purpose of this review was to summarize the application of vitamin C in orthopaedic practices and to identify potential areas for future study.

[Nutrimuscle-Diététique]

Traduction de l'étude

La vitamine C dans les pratiques orthopédiques: concepts actuels, idées nouvelles et perspectives d'avenir
Bennett Oakes J Ortho Res 10 décembre 2020

La vitamine C (acide ascorbique) est un antioxydant important qui a été largement appliqué dans le domaine de l'orthopédie. Les recherches actuelles sur la vitamine C examinent le rôle de la molécule dans la physiologie des os et des tendons, ainsi que le remplacement articulaire et la douleur postopératoire.

La plupart des études en laboratoire et sur l'homme associent l'utilisation de la vitamine C à une amélioration de la santé des os et de la guérison des tendons. La littérature récente soutient modérément l'utilisation de la vitamine C pour améliorer les résultats fonctionnels, réduire la douleur postopératoire et prévenir le syndrome douloureux régional complexe à la suite de procédures orthopédiques. L'utilisation périopératoire de la vitamine C chez les patients subissant une chirurgie de remplacement articulaire et une reconstruction du ligament croisé antérieur est toujours à l'étude. Dans l'ensemble, des essais humains de haute qualité sont nécessaires pour confirmer si la vitamine C peut potentialiser les résultats des procédures orthopédiques et pour déterminer la posologie et les moyens d'administration optimaux pour maximiser ses avantages proposés. Le but de cette revue était de résumer l'application de la vitamine C dans les pratiques orthopédiques et d'identifier les domaines potentiels pour une étude future.