Dietary Intake of Phylloquinone in Relation to All-Cause Mortality in a Mediterranean Population at High Cardiovascular Risk
Ann Nutr Metab 2013;62(suppl 2): P022 Martí Juanola-Falgarona
Background and Objectives: Vitamin K has been associated with a reduced risk of CHD and fatal cancer. Dietary menaquinones intake has been associated with cancer mortality. However, the association between the dietary intake of vitamin K and allcause mortality has not been evaluated in a Mediterranean population at high cardiovascular risk.
Methods: A prospective analysis was conducted in 7216 participants in the framework of the PREDIMED cohort (median
follow-up: 4.8y). Energy and nutrient intakes were evaluated using a previously validated 137-item food frequency questionnaire. Dietary phylloquinone and menaquinone intake was calculated using the USDA database and previous published data, 24 Ann Nutr Metab 2013;62(suppl 2):1–90 Abstracts
respectively. All-cause mortality was verified by medical records and consultation of National Death Index. Cox proportional hazard models were fitted to assess the relative risk of all-cause mortality.
Results: At baseline, energy-adjusted dietary phylloquinone intake was associated with a significantly reduced risk of allcause mortality after controlling for potential confounders (HR: 0.64; 95% CI: 0.43, 0.96). No significant associations were found between quartiles of energy adjusted dietary menaquinones intake and risk of all-cause mortality. In a longitudinal manner, subjects who increase their consumption of vitamin K, phylloquinone or menaquinone, had a lower risk of all-cause mortality (HR: 0.58; 95% CI: 0.45, 0.74 and HR: 0.59; 95% CI: 0.45, 0.78, respectively) compared with subjects who decrease their consumption.
Conclusion: The results showed that an increase of dietary intake of vitamin K is related with a reduced risk of all-cause mortality in a Mediterranean population at high cardiovascular risk.
