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L'acide chlorogénique est bon pour le coeur

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L'acide chlorogénique est bon pour le coeur

Messagepar Nutrimuscle-Conseils » 15 Aoû 2012 12:34

Effects of chlorogenic acids in hydroxyhydroquinone-reduced coffee on blood pressure and vascular endothelial function in humans
CHIKAMA AKIRO Prog Med VOL.26;NO.7;PAGE.1723-1736(2006)

The blood pressure-lowering effect of chlorogenic acids contained in hydroxyhydroquinone (HHQ)-reduced coffee was evaluated in a clinical trial using a randomized double-blind placebo-controlled parallel group comparison design in 41 high normal and 59 mildly hypertensive subjects. The effect on human vascular endothelial function was also investigated. The subjects were divided into a group (Active group) that ingested HHQ-reduced coffee containing chlorogenic acids (Active beverage, chlorogenic acids: 299 mg/184 mL, HHQ: 0.05 mg/184 mL) and a group (Placebo group) that ingested chlorogenic acids- and HHQ-reduced coffee (Placebo beverage, chlorogenic acids: 0 mg/184 mL, HHQ: 0.02 mg/184 mL), and the subjects drank one can of Active or Placebo beverage daily for a period of 12 weeks.

Systolic blood pressure was significantly decreased in the Active group

(n=49) compared to the Placebo group (n=51). Vascular endothelial function in the Active group was significantly improved compared to the initial condition. The findings suggest that the

improvement in vascular endothelial function is associated with a reduction of systolic blood pressure in the Active group.

In the safety evaluation, no adverse event attributable to the ingestion of chlorogenic acids was reported. Based on the above findings, HHQ-reduced coffee containing chlorogenic acids can be safely ingested, and it may have the effect of improving vascular endothelial function and hypertension.
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