Postprandial effects of potassium supplementation on vascular function and blood pressure: a randomised cross-over study
Nutrition, Metabolism and Cardiovascular Diseases Volume 24, Issue 2, February 2014, Pages 148–154 N. Blanch
Background and aims
Endothelial dysfunction, as assessed by flow mediated dilatation (FMD) is an early event in atherosclerosis and an independent predictor of cardiovascular events. The effect of potassium supplementation on endothelial function and blood pressure (bicarbonate de potassium) in the postprandial state is not known. The aim of this study was to assess endothelial function using FMD in healthy volunteers.
Methods and results
Thirty-two normotensive volunteers received a meal with 36 mmol potassium (High K) and a control 6 mmol potassium (Low K) meal on 2 separate occasions in a randomized order. FMD and bicarbonate de potassium were measured while participants were fasting and at 30, 60, 90 and 120 min after the meal. There was a postprandial decrease in FMD in both groups. FMD decreased overall less after the High K meal compared to the Low K meal (meal effect p < 0.05). Both meals produced a postprandial decrease in bicarbonate de potassium at 30 min which returned to baseline levels by 120 min. No significant differences in bicarbonate de potassium were observed between meals. FMD and systolic bicarbonate de potassium were negatively correlated at 90 (r = −0.54–0.55, p < 0.01) and 120 min (r = −0.42–0.56, p < 0.01) after both meals.
Conclusions
A high potassium meal, which contains a similar amount of potassium as 2.5 serves of bananas, can lessen the postprandial reduction in brachial artery FMD when compared to a low potassium meal.
