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Quelle alimentation contre l'acné?

Messagepar Nutrimuscle-Conseils » 13 Aoû 2020 11:40

Diet and Acne—Challenges of Translating Nutritional Epidemiologic Research Into Clinical Practice
John S. Barbieri, JAMA Dermatol. 2020;156(8):841-843.

There is growing evidence that diet may influence the incidence and severity of acne vulgaris, one of the most common skin conditions in the US.1 Much of the previous literature on the role of diet in acne has focused on the association of milk consumption and high glycemic-load diet with acne. For instance, milk consumption is thought to increase insulin and insulinlike-growth factor 1 levels, which can induce lipogenesis and proliferation of both keratinocytes and sebocytes.2,3 In addition, insulinlike-growth factor 1 can stimulate androgen synthesis and decrease production of sex hormone–binding globulin. Bovine insulinlike-growth factor 1 and androgens present in milk may also promote the development of acne.2,3

Observational studies, including a recent meta-analysis of 14 studies, have suggested an association between acne and milk intake.4 There is uncertainty whether milkfat percentage (ie, whole, low-fat, and skim) influences the strength of this association.

Whey protein, which represents 20% of the protein in cow’s milk, has also been suggested to contribute to the development of acne, and a small case series of 5 men found that discontinuation of whey protein supplement use resulted in apparent improvement of their acne.5

Similar to milk consumption, high glycemic-load diets have also been proposed to increase insulin and insulinlike-growth factor 1 levels, which could result in the development of acne.3 However, while observational studies and small trials have supported an association between high glycemic-load diet and acne,6,7 a Cochrane review on complementary acne therapies8 found insufficient evidence to support a low glycemic-load diet for the management of acne.

Although there have been several observational studies and small trials on the role of diet in acne, these studies have been limited by focusing on only a few domains of diet. In results from the NutriNet-Santé study published in this issue of JAMA Dermatology, Penso and colleagues9 report on the association between a broad range of dietary behaviors and adult acne. The NutriNet-Santé study is a prospective, observational cohort study that includes extensive dietary phenotyping via repeated online questionnaires. This cohort has been previously used to evaluate dietary associations with other inflammatory skin diseases, such as psoriasis.10 In November 2018, an acne questionnaire was distributed to this cohort to gather patient-reported data on acne history, which were used for this study. After adjusting for potential confounders, such as age, sex, total energy intake, smoking status, physical activity, and body mass index, consumption of milk (per glass: adjusted odds ratio [aOR], 1.12; 95% CI, 1.00-1.25), sugary beverages (per glass: aOR 1.18; 95% CI 1.01-1.38), and fatty and sugary products (per portion: aOR 1.53; 95% CI 1.09-2.16) were each found to be independently associated with current acne. Penso and colleagues9 also performed a principal components analysis in which a healthy dietary pattern was associated with decreased odds of current acne and a fatty and sugary dietary pattern was associated with increased odds of current acne. Similar patterns were observed in a subgroup analysis of women with acne.

These findings are largely in line with prior observational studies suggesting an association between milk consumption and high glycemic-load diet with acne.4,6,7 A small study in which college students were randomized to consume a milk chocolate bar or equivalent glycemic load of jelly beans reported increased acne activity in the chocolate bar group.11 Although an association between milk chocolate consumption and acne was noted in the univariate analysis, the present study by Penso and colleagues9 did not identify any association between milk or dark chocolate consumption and acne in their multivariate model.

The study by Penso and colleagues9 has several strengths, including its large sample size, attempts to control for potential confounders, and the comprehensive assessment of dietary habits of the participants. However, the study is not without limitations. Since the NutriNet-Santé cohort does not have data on milkfat percentage or whey protein consumption, the potential association between these factors and acne could not be assessed. In addition, given that many of the identified dietary associations in the multivariate analysis were only weakly significant (P = .01 to .05), there is a concern for spurious associations given the large number of dietary factors evaluated, although the similar findings in the principal coordinates analysis are reassuring.

As the authors discuss, an important challenge of nutritional epidemiologic research is the inability to determine whether there is a causal association between diet and the presence of acne. Unfortunately, associations identified in nutritional epidemiologic research are often unable to be replicated when evaluated in randomized trials.12 Given the complexity of diet and potential for confounding and selective reporting bias, some suggestions to improve the quality of nutritional epidemiologic research include improving transparency with prespecified analytic plans, increased data sharing, and independent analyses by other nutritional epidemiologists, including contrarians, to replicate study findings.13

In addition, effect sizes observed in this study were generally small (eg, ORs <1.2) and an association between diet and acne may not be clinically meaningful for many patients. Given these limitations, the findings of this study should be interpreted with caution with respect to clinical practice. There is a need for prospective, randomized trials to evaluate the influence of diet on acne. A small, 32-patient trial in Korea found that individuals randomized to a low glycemic-load diet had decreased sebaceous gland activity, greater reductions in acne lesions, and higher patient self-assessment scores at 10 weeks than those in the control diet group.6 Similar findings were found in an Australian trial involving 43 young adult men with acne.7 Future trials that assess both the mechanistic and clinical influence of diet on acne are needed to translate hypotheses generated from nutritional epidemiologic research into clinical practice.

Given the uncertainty surrounding both causal inference as well as the magnitude of the association between diet and acne, dietary interventions may be better thought of as adjunctive strategies rather than primary treatment options. Because some dietary interventions, such as avoiding dairy products, may have other relevant effects (eg, reduced calcium and vitamin D intake), they should be cautiously implemented. Nevertheless, given the potential overall health benefits of a healthy or low glycemic-load diet, and 2 small trials supporting its effectiveness in acne, a low glycemic-load diet is a reasonable recommendation for patients looking for dietary modifications that may improve their acne.

Overall, it is encouraging to see that the relatively comprehensive evaluation of the association between dietary factors and acne by Penso and colleagues9 is largely aligned with prior research identifying an association between high glycemic-load foods and milk consumption with acne. However, before we can confidently make dietary recommendations for patients with acne, trials are needed to evaluate whether dietary interventions can improve or prevent acne and how the effect size of such interventions compares with other standard treatment modalities.
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Re: Quelle alimentation contre l'acné?

Messagepar Nutrimuscle-Conseils » 13 Aoû 2020 11:46

Association Between Adult Acne and Dietary Behaviors
Findings From the NutriNet-Santé Prospective Cohort Study

Laetitia Penso, JAMA Dermatol. 2020;156(8):854-862.

Key Points
Question Is dietary behavior associated with acne in adults?

Findings In this cross-sectional study of 24 452 participants in the French NutriNet-Santé study, the consumption of fatty and sugary products, sugary beverages, and milk was associated with current acne in adults. This association was noted after adjustment for sociodemographic variables and confounding factors, including daily energy intake, the number of dietary records completed, and depressive symptoms.

Meaning These findings suggest that a Western diet (ie, rich in animal products and fatty and sugary foods) is associated with the presence of acne in adults.

Abstract
Importance Acne is a chronic, multifactorial inflammatory disease. The association between consumption of dairy products and fatty and sugary foods and occurrence and progression of acne remains unclear.

Objective To assess the association between dietary behavior and current acne in adults.

Design, Setting, and Participants A cross-sectional study was performed as part of the NutriNet-Santé study, which is an ongoing observational, web-based cohort study that was launched in France in May 2009. The present study was conducted from November 14, 2018, to July 8, 2019. A total of 24 452 participants completed an online self-questionnaire to categorize their acne status: never acne, past acne, or current acne. Associations between dietary behavior (food intake, nutrient intake, and the dietary pattern derived from a principal component analysis) and current or past acne were studied in multinomial logistic regression models adjusted for potential confounding variables (age, sex, physical activity, smoking status, educational level, daily energy intake, number of dietary records completed, and depressive symptoms).

Results The 24 452 participants (mean [SD] age, 57 [14] years; 18 327 women [75%]) completed at least 3 dietary records. Of these, 11 324 individuals (46%) reported past or current acne. After adjustment, there was a significant association between current acne and the consumption of fatty and sugary products (adjusted odds ratio [aOR], 1.54; 95% CI, 1.09-2.16), sugary beverages (aOR, 1.18; 95% CI, 1.01-1.38), and milk (aOR, 1.12; 95% CI, 1.00-1.25). An energy-dense dietary pattern (high consumption of fatty and sugary products) was associated with current acne (aOR, 1.13; 95% CI, 1.05-1.18).

Conclusions and Relevance In this study, consumption of milk, sugary beverages, and fatty and sugary products appeared to be associated with current acne in adults. Further large-scale studies are warranted to investigate more closely the associations between diet and adult acne.
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Re: Quelle alimentation contre l'acné?

Messagepar Nutrimuscle-Diététique » 14 Aoû 2020 10:05

Traduction de l'étude :wink:

Association entre l'acné chez l'adulte et les comportements alimentaires
Résultats de l'étude de cohorte prospective NutriNet-Santé

Laetitia Penso, JAMA Dermatol. 2020; 156 (8): 854-862.

Points clés
Question Le comportement alimentaire est-il associé à l'acné chez les adultes?

Résultats Dans cette étude transversale menée auprès de 24452 participants à l'étude française NutriNet-Santé, la consommation de produits gras et sucrés, de boissons sucrées et de lait était associée à l'acné actuelle chez les adultes. Cette association a été notée après ajustement pour les variables sociodémographiques et les facteurs de confusion, y compris l'apport énergétique quotidien, le nombre d'enregistrements alimentaires complétés et les symptômes dépressifs.

Signification Ces résultats suggèrent qu'une alimentation occidentale (c'est-à-dire riche en produits animaux et en aliments gras et sucrés) est associée à la présence d'acné chez les adultes.

Abstrait
Importance L'acné est une maladie inflammatoire chronique et multifactorielle. L'association entre la consommation de produits laitiers et d'aliments gras et sucrés et l'apparition et la progression de l'acné reste incertaine.

Objectif Évaluer l'association entre le comportement alimentaire et l'acné actuelle chez les adultes.

Conception, contexte et participants Une étude transversale a été réalisée dans le cadre de l'étude NutriNet-Santé, une étude de cohorte observationnelle en ligne lancée en France en mai 2009. La présente étude a été menée à partir du 14 novembre. , 2018, au 8 juillet 2019. Un total de 24452 participants ont rempli un auto-questionnaire en ligne pour classer leur état d'acné: jamais acné, acné passée ou acné actuelle. Les associations entre le comportement alimentaire (apport alimentaire, apport nutritionnel et régime alimentaire dérivé d'une analyse en composantes principales) et l'acné actuelle ou passée ont été étudiées dans des modèles de régression logistique multinomiale ajustés pour les variables confondantes potentielles (âge, sexe, activité physique, tabagisme, niveau d'éducation, apport énergétique quotidien, nombre d'enregistrements alimentaires complétés et symptômes dépressifs).

Résultats Les 24452 participants (âge moyen [ET], 57 [14] ans; 18327 femmes [75%]) ont rempli au moins 3 relevés alimentaires. De ce nombre, 11324 personnes (46%) ont signalé une acné passée ou actuelle. Après ajustement, il y avait une association significative entre l'acné actuelle et la consommation de produits gras et sucrés (odds ratio ajusté [aOR], 1,54; IC 95%, 1,09-2,16), boissons sucrées (aOR, 1,18; IC 95%, 1,01 -1,38) et le lait (aOR, 1,12; IC à 95%, 1,00-1,25). Un régime alimentaire dense en énergie (consommation élevée de produits gras et sucrés) était associé à l'acné actuelle (aOR, 1,13; IC à 95%, 1,05-1,18).

Conclusions et pertinence Dans cette étude, la consommation de lait, de boissons sucrées et de produits gras et sucrés semble être associée à l'acné actuelle chez les adultes. D'autres études à grande échelle sont nécessaires pour étudier de plus près les associations entre l'alimentation et l'acné chez l'adulte.
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Re: Quelle alimentation contre l'acné?

Messagepar Nutrimuscle-Conseils » 3 Juil 2022 10:59

Association between Nutritional Behaviours and Acne-Related Quality of Life in a Population of Polish Male Adolescents
by Katarzyna Łożyńska Nutrients 2022, 14(13), 2677;

Acne vulgaris is diagnosed in the majority of adolescents, decreasing their quality of life, while the diet may influence its aetiology in a gender-dependent manner. The aim of the study was to analyse associations between nutritional behaviours and acne-related quality of life in a population of Polish male adolescents. The study was conducted on a population of Polish secondary school adolescents (a studied sample of 925 adolescents), while the random quota sampling procedure of secondary schools was applied. To assess acne-related quality of life, the Acne Quality of Life (AQoL) Scale and Acne Disability Questionnaire (ADQ) were applied, while the Social Quality of Life (SOCQOL) Score and Cardiff Acne Disability Index (CADI) were calculated. To assess the diet, an Acne-specific Food Frequency Questionnaire (Acne-FFQ) was applied. Neither for the ADQ results, nor for the CADI calculated on the basis of ADQ, was there an association with dietary intake (p > 0.05).

The results of the SOCQOL Score (calculated on the basis of AQoL) were positively correlated with the intake of fish (p = 0.0085; R = 0.1144), salty snacks (p = 0.0495; R = 0.0854), and non-chocolate confectionary (p = 0.0078; R = 0.1156). In a group of respondents declaring any acne-related quality of life problems in AQoL, while compared with those declaring no such problems, higher intakes of dairy beverages other than milk (p = 0.0063), white bread (p < 0.0001), other white cereal products (p < 0.0001), fast foods (p = 0.0006), salty snacks (p < 0.0001), chocolate confectionary (p < 0.0001), and other confectionary (p < 0.0001), but lower intake of wholegrain bread (p = 0.0084) were observed.

It may be concluded that acne-related quality of life is associated with dietary intake in a population of Polish male adolescents. In the studied population, the most prominent influencing factors were salty snacks and non-chocolate confectionary, with both of them having a proacnegenic effect.
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Re: Quelle alimentation contre l'acné?

Messagepar Nutrimuscle-Diététique » 5 Juil 2022 17:30

Traduction de l'étude :wink:

Association entre les comportements nutritionnels et la qualité de vie liée à l'acné dans une population d'adolescents masculins polonais
par Katarzyna Łożyńska Nutrients 2022, 14(13), 2677 ;

L'acné vulgaire est diagnostiquée chez la majorité des adolescents, diminuant leur qualité de vie, tandis que le régime alimentaire peut influencer son étiologie de manière dépendante du sexe. Le but de l'étude était d'analyser les associations entre les comportements nutritionnels et la qualité de vie liée à l'acné dans une population d'adolescents masculins polonais. L'étude a été menée sur une population d'adolescents du secondaire polonais (un échantillon étudié de 925 adolescents), tandis que la procédure d'échantillonnage par quota aléatoire des écoles secondaires a été appliquée. Pour évaluer la qualité de vie liée à l'acné, l'échelle Acne Quality of Life (AQoL) et l'Acne Disability Questionnaire (ADQ) ont été appliqués, tandis que le score Social Quality of Life (SOCQOL) et l'indice Cardiff Acne Disability Index (CADI) ont été calculés. Pour évaluer le régime alimentaire, un questionnaire de fréquence alimentaire spécifique à l'acné (Acne-FFQ) a été appliqué. Ni pour les résultats de l'ADQ, ni pour le CADI calculé sur la base de l'ADQ, il n'y a eu d'association avec l'apport alimentaire (p > 0,05).

Les résultats du score SOCQOL (calculé sur la base de l'AQoL) étaient positivement corrélés avec la consommation de poisson (p = 0,0085 ; R = 0,1144), de collations salées (p = 0,0495 ; R = 0,0854) et de confiserie non chocolatée ( p = 0,0078 ; R = 0,1156). Dans un groupe de répondants déclarant des problèmes de qualité de vie liés à l'acné dans l'AQoL, alors que par rapport à ceux ne déclarant aucun de ces problèmes, des consommations plus élevées de boissons laitières autres que le lait (p = 0,0063), de pain blanc (p < 0,0001), d'autres produits céréaliers (p < 0,0001), restauration rapide (p = 0,0006), snacks salés (p < 0,0001), confiseries chocolatées (p < 0,0001) et autres confiseries (p < 0,0001), mais moindre consommation de pain complet (p = 0,0084) ont été observées.

On peut conclure que la qualité de vie liée à l'acné est associée à l'apport alimentaire dans une population d'adolescents masculins polonais. Dans la population étudiée, les facteurs d'influence les plus importants étaient les collations salées et les confiseries non chocolatées, les deux ayant un effet proacnégénique
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Re: Quelle alimentation contre l'acné?

Messagepar Nutrimuscle-Conseils » 1 Fév 2023 05:50

Biochemical and hormonal abnormalities in adult female acne
Amit Kumar Meena J Cosmetic derm 06 January 2023

Background
Prevalence of adult patients with acne is increasing and women comprise majority of the cases. There is lack of data on biochemical and hormonal abnormalities in adult female acne (AFA).

Aims
To evaluate biochemical and hormonal parameters in 60 patients of AFA.

Methods
A cross-sectional observational study conducted from November 2018 to March 2020 in Dermatology outpatient department of a tertiary care hospital in North India. Adult females (age > 25 years) with a clinical diagnosis of acne were included in the study.

Results
60 cases of AFA were included. The age ranged between 26–41 years with mean age at presentation being 29.45 years. 53.3% patients had persistent acne while 46.7% had late-onset acne. 50% patients had history of premenstrual flare-up of their acne. Raised FBG was found in 25% patients. 10% had raised serum insulin levels. HOMA-IR index was deranged in 55% patients. At least one lipid alteration was reported in 91.6% of patients. In hormonal parameters, raised TT was present in 6.7%, LH in 3.3%, FSH in 18.3%, prolactin in 3.3%, and TSH in 15%. No association was found between acne severity and biochemical and hormonal parameters.

Conclusions
Our study highlighted the importance of measuring lipid profile in AFA and calculating HOMA-IR index for measuring insulin resistance rather than simply measuring serum insulin levels. In our study, additional parameter deranged in significant number of patients was FBG. Hence, we recommend routine screening of lipid profile, FBG and calculation of HOMA-IR index in AFA.
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Re: Quelle alimentation contre l'acné?

Messagepar Nutrimuscle-Diététique » 1 Fév 2023 16:24

Traduction de l'étude :wink:

Anomalies biochimiques et hormonales dans l'acné de la femme adulte
Amit Kumar Meena J Dermo cosmétique 06 janvier 2023

Fond
La prévalence des patients adultes souffrant d'acné augmente et les femmes représentent la majorité des cas. Il y a un manque de données sur les anomalies biochimiques et hormonales dans l'acné de la femme adulte (AFA).

Objectifs
Évaluer les paramètres biochimiques et hormonaux chez 60 patients atteints d'AFA.

Méthodes
Une étude observationnelle transversale menée de novembre 2018 à mars 2020 dans le service ambulatoire de dermatologie d'un hôpital de soins tertiaires du nord de l'Inde. Des femmes adultes (âge > 25 ans) avec un diagnostic clinique d'acné ont été incluses dans l'étude.

Résultats
60 cas d'AFA ont été inclus. L'âge variait entre 26 et 41 ans, l'âge moyen à la présentation étant de 29,45 ans. 53,3% des patients avaient une acné persistante tandis que 46,7% avaient une acné tardive. 50% des patientes avaient des antécédents de poussée prémenstruelle de leur acné. FBG élevé a été trouvé chez 25% des patients. 10 % avaient des niveaux élevés d'insuline sérique. L'indice HOMA-IR était perturbé chez 55 % des patients. Au moins une altération lipidique a été rapportée chez 91,6 % des patients. Dans les paramètres hormonaux, le TT élevé était présent chez 6,7 %, la LH chez 3,3 %, la FSH chez 18,3 %, la prolactine chez 3,3 % et la TSH chez 15 %. Aucune association n'a été trouvée entre la sévérité de l'acné et les paramètres biochimiques et hormonaux.

conclusion
Notre étude a mis en évidence l'importance de mesurer le profil lipidique dans l'AFA et de calculer l'indice HOMA-IR pour mesurer la résistance à l'insuline plutôt que de simplement mesurer les niveaux d'insuline sérique. Dans notre étude, un paramètre supplémentaire dérangé chez un nombre significatif de patients était le FBG. Par conséquent, nous recommandons un dépistage systématique du profil lipidique, du FBG et du calcul de l'indice HOMA-IR dans l'AFA.
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Re: Quelle alimentation contre l'acné?

Messagepar Nutrimuscle-Conseils » 14 Fév 2023 13:03

The effect of the ketogenic diet on Acne: Could it be a therapeutic tool?
Luigi Barrea Critical Reviews in Food Science and Nutrition 13 Feb 2023

Acne is a chronic inflammatory disease of the pilosebaceous unit resulting from androgen-induced increased sebum production, altered keratinization, inflammation, and bacterial colonization of the hair follicles of the face, neck, chest and back by Propionibacterium acnes.

Overall, inflammation and immune responses are strongly implicated in the pathogenesis of acne. Although early colonization with Propionibacterium acnes and family history may play an important role in the disease, it remains unclear exactly what triggers acne and how treatment affects disease progression. The influence of diet on acne disease is a growing research topic, yet few studies have examined the effects of diet on the development and clinical severity of acne disease, and the results have often been contradictory.

Interestingly, very low-calorie ketogenic diet (VLCKD) has been associated with both significant reductions in body weight and inflammatory status through the production of ketone bodies and thus it has been expected to reduce the exacerbation of clinical manifestations or even block the trigger of acne disease. Given the paucity of studies regarding the implementation of VLCKD in the management of acne, this review aims to provide evidence from the available scientific literature to support the speculative use of VLCKD in the treatment of acne.
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Re: Quelle alimentation contre l'acné?

Messagepar Nutrimuscle-Diététique » 14 Fév 2023 13:47

Traduction de l'étude :wink:

L'effet du régime cétogène sur l'acné : Pourrait-il être un outil thérapeutique ?
Revues critiques de Luigi Barrea en science alimentaire et nutrition 13 février 2023

L'acné est une maladie inflammatoire chronique de l'unité pilosébacée résultant de l'augmentation de la production de sébum induite par les androgènes, de la kératinisation altérée, de l'inflammation et de la colonisation bactérienne des follicules pileux du visage, du cou, de la poitrine et du dos par Propionibacterium acnes.

Dans l'ensemble, l'inflammation et les réponses immunitaires sont fortement impliquées dans la pathogenèse de l'acné. Bien que la colonisation précoce par Propionibacterium acnes et les antécédents familiaux puissent jouer un rôle important dans la maladie, on ne sait pas exactement ce qui déclenche l'acné et comment le traitement affecte la progression de la maladie. L'influence de l'alimentation sur la maladie acnéique est un sujet de recherche croissant, mais peu d'études ont examiné les effets de l'alimentation sur le développement et la gravité clinique de la maladie acnéique, et les résultats ont souvent été contradictoires.

Fait intéressant, le régime cétogène très hypocalorique (VLCKD) a été associé à la fois à des réductions significatives du poids corporel et de l'état inflammatoire grâce à la production de corps cétoniques et on s'attend donc à ce qu'il réduise l'exacerbation des manifestations cliniques ou même bloque le déclencheur de l'acné. maladie
. Compte tenu de la rareté des études concernant la mise en œuvre du VLCKD dans la prise en charge de l'acné, cette revue vise à fournir des preuves issues de la littérature scientifique disponible pour étayer l'utilisation spéculative du VLCKD dans le traitement de l'acné.
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Re: Quelle alimentation contre l'acné?

Messagepar Nutrimuscle-Conseils » 27 Oct 2023 09:58

Safety and Effectiveness of Oral Nutraceuticals for Treating Acne
A Systematic Review

Ali Shields JAMA Dermatol. Published online October 25, 2023.

Key Points
Question Are oral nutraceuticals a safe and effective treatment for patients with acne?

Findings In this systematic review of 3346 participants in 42 unique studies, 4 good-quality studies of nutraceuticals demonstrated effectiveness of vitamin D, green tea extract, probiotics, and cheongsangbangpoong-tang in the treatment of acne. Several other fair-quality studies demonstrated effectiveness of pantothenic acid, ω-3 and ω-6 fatty acids, and probiotics.

Meaning These findings suggest a possible role for nutraceutical supplements in the treatment of acne; physicians should engage in shared decision-making with patients regarding their use.

Abstract
Importance Patients with acne are interested in nutraceuticals as a potential treatment option. However, there is uncertainty regarding the efficacy and safety of these products.

Objective To evaluate the evidence for oral nutraceuticals in the treatment of acne.

Evidence Review The PubMed, Embase, Cochrane Central Register of Controlled Trials, and Web of Science databases were searched from inception through January 30, 2023, to identify randomized clinical trials evaluating oral nutraceutical interventions (ie, vitamins and minerals, botanical extracts, prebiotics, and probiotics) in individuals with acne. Clinician-reported outcomes (eg, investigator global assessment, lesion counts), patient-reported outcomes (eg, quality of life), and adverse events were extracted from the included studies. The quality of evidence was assessed using the Cochrane Risk of Bias checklist tool for randomized clinical trials. Based on the Risk of Bias tool, articles were converted to Agency for Healthcare Research and Quality standards of good, fair, or poor quality.

Findings A total of 2582 abstracts were identified in the database search, 42 of which met inclusion criteria (a total of 3346 participants). Studies of fair or good quality showed the potential benefit of vitamins B5 and D, botanical extracts (green tea), probiotics, and ω-3 fatty acids in the treatment of acne. These interventions were most frequently associated with decreased lesion counts or improved investigator global assessment scores. Adverse effects were rare for most of the therapies evaluated, but gastrointestinal tract adverse effects were reported for zinc therapy.

Conclusions and Relevance This systematic review suggests a possible role for nutraceutical supplements in the treatment of acne. Physicians should be prepared to discuss the evidence regarding the potential role of nutraceuticals with patients. Many studies were of small size, and future research should focus on larger randomized clinical trials to assess the utility of nutraceuticals in the treatment of acne.
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Re: Quelle alimentation contre l'acné?

Messagepar Nutrimuscle-Conseils » 27 Oct 2023 10:04

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