afin de réduire la production d'IL-6, il faut boire du dextrose ou de la maltodextrine durant l'entraînement
Overload-induced skeletal muscle extracellular matrix remodelling and myofibre growth in mice lacking IL-6
Methods: Male C57/BL6 (WT) and C57/BL6 × IL-6−/− (IL-6−/−) mice (10 weeks of age) were assigned to either a sham control or synergist ablation OV treatments for 3, 21 or 56 days.
Result: Plantaris muscle mass increased 59% in WT and 116% in IL-6−/− mice after 21 day OV. Myofibre CSA was also increased by 21 day OV in both WT and IL-6−/− mice. OV induced a twofold greater increase in the volume of non-contractile tissue in IL-6−/− muscle compared to WT. OV also induced a significantly greater accumulation of hydroxyproline and procollagen-1 mRNA in IL-6−/− muscle, when compared with WT muscle after 21 day OV. Transforming growth factor-β and insulin-like growth factor-1 mRNA expression were also induced to a greater extent in IL-6−/− muscle when compared with WT muscle after 21 day OV. There was no effect of IL-6 loss on the induction of myogenin, and cyclin D1 mRNA expression after 3 day OV. However, MyoD mRNA expression in 3 day OV IL-6−/− muscle was attenuated when compared with WT OV mice.
Conclusion: IL-6 appears to be necessary for the normal regulation of extracellular matrix remodelling during OV-induced growth.
