Témoignage: Je suis diabétique type 1 et pourtant...

[bodynat59]

tu n'as pas dû te pencher beaucoup sur le sujet alors... cherche mieux

Oui j'ai cherché j'ai eu des informations qui concordent avec ce que j'avais dit. Aussi, j'ai RDV avec mon endocrinologue fin novembre, je lui en parlerai.

[Nutrimuscle-Conseils]

il faut lui en parler diplomatiquement car j'ai peur qu'il ne comprenne pas

[bodynat59]

Je ne sais pas, à l'origine je n'y vais pas pour ça mais je vais lui en toucher un mot.

[Nutrimuscle-Conseils]

je prends les paris qu'il te prend pour un fou... sauf si tu attends encore 10 ou 20 ans

[bodynat59]

Je demanderai de toute façon, quelque soit sa réponse je vous en informerai.

[Nutrimuscle-Conseils]

Alterations in skeletal muscle repair in young adults with type 1 diabetes mellitus
Athan G. Dial American Journal of Physiology-Cell Physiology, Volume 321, Issue 5 2021

Though preclinical models of type 1 diabetes (T1D) exhibit impaired muscle regeneration, this has yet to be investigated in humans with T1D. Here, we investigated the impact of damaging exercise (eccentric quadriceps contractions) in 18 physically active young adults with and without T1D. Pre- and postexercise (48 h and 96 h), the participants provided blood samples, vastus lateralis biopsies, and performed maximal voluntary quadriceps contractions (MVCs). Skeletal muscle sarcolemmal integrity, extracellular matrix (ECM) content, and satellite cell (SC) content/proliferation were assessed by immunofluorescence. Transmission electron microscopy was used to quantify ultrastructural damage. MVC was comparable between T1D and controls before exercise.

Postexercise, MVC was decreased in both groups, but subjects with T1D exhibited moderately lower strength recovery at both 48 h and 96 h. Serum creatine kinase, an indicator of muscle damage, was moderately higher in participants with T1D at rest and exhibited a small elevation 96 h postexercise. Participants with T1D showed lower SC content at all timepoints and demonstrated a moderate delay in SC proliferation after exercise. A greater number of myofibers exhibited sarcolemmal damage (disrupted dystrophin) and increased ECM (laminin) content in participants with T1D despite no differences between groups in ultrastructural damage as assessed by electron microscopy. Finally, transcriptomic analyses revealed dysregulated gene networks involving RNA translation and mitochondrial respiration, providing potential explanations for previous observations of mitochondrial dysfunction in similar cohorts with T1D.

Our findings indicate that skeletal muscle in young adults with moderately controlled T1D is altered after damaging exercise, suggesting that longer recovery times following intense exercise may be necessary.

[bodynat59]

Merci

Traduction de la dernière partie :

Nos résultats indiquent que le muscle squelettique chez les jeunes adultes atteints de DT1 modérément contrôlé est altéré après un exercice dommageable, ce qui suggère que des temps de récupération plus longs après un exercice intense peuvent être nécessaires.