20 x 1 g par jour augmente la rétention de créatine de 65 % par rapport à 4 x 5 g
Urinary creatine and methylamine excretion following 4 5 g · day-1 or 20 1 g · day-1 of creatine monohydrate for 5 days
Authors: Craig Sale a; Roger C. Harris b; James Florance b; Alain Kumps c; Robertine Sanvura c; Jacques R. Poortmans d
Published in: Journal of Sports Sciences, Volume 27, Issue 7 May 2009 , pages 759 - 766
we examined the effect of two creatine monohydrate supplementation regimes on 24-h urinary creatine and methylamine excretion. Nine male participants completed two trials, separated by 6 weeks. Participants ingested 4 5 g · day-1 creatine monohydrate for 5 days in one trial and 20 1 g · day-1 for 5 days in the other. We collected 24-h urine samples on 2 baseline days (days 1-2), during 5 days of supplementation (days 3-7), and for 2 days post-supplementation (days 8-9). Urine was assayed for creatine using high-performance liquid chromatography and methylamine using gas chromatography. Less creatine was excreted following the 20 1 g · day-1 regime (49.25 ± 10.53 g) than the 4 5 g · day-1 regime (62.32 ± 9.36 g) (mean ± s; P < 0.05). Mean total excretion of methylamine (n = 6) over days 3-7 was 8.61 ± 7.58 mg and 24.81 ± 25.76 mg on the 20 1 g · day-1 and 4 5 g · day-1 regimes, respectively (P < 0.05). The lower excretion of creatine using 20 1 g · day-1 doses suggests a greater retention in the body and most probably in the muscle. Lower and more frequent doses of creatine monohydrate appear to further attenuate formation of methylamine.
